Cargando…

The Genetic Program of Pancreatic β-Cell Replication In Vivo

The molecular program underlying infrequent replication of pancreatic β-cells remains largely inaccessible. Using transgenic mice expressing green fluorescent protein in cycling cells, we sorted live, replicating β-cells and determined their transcriptome. Replicating β-cells upregulate hundreds of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Klochendler, Agnes, Caspi, Inbal, Corem, Noa, Moran, Maya, Friedlich, Oriel, Elgavish, Sharona, Nevo, Yuval, Helman, Aharon, Glaser, Benjamin, Eden, Amir, Itzkovitz, Shalev, Dor, Yuval
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2016
Materias:	Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915587/ https://www.ncbi.nlm.nih.gov/pubmed/26993067 http://dx.doi.org/10.2337/db16-0003

Ejemplares similares

Relative Expression of a Dominant Mutated ABCC8 Allele Determines the Clinical Manifestation of Congenital Hyperinsulinism
por: Shemer, Ruth, et al.
Publicado: (2012)

Systemic Regulation of the Age-Related Decline of Pancreatic β-Cell Replication
por: Salpeter, Seth J., et al.
Publicado: (2013)

Metabolomic Changes in Serum of Children with Different Clinical Diagnoses of Malnutrition(1)(2)(3)
por: Di Giovanni, Valeria, et al.
Publicado: (2016)

Metabolic Footprinting of Fermented Milk Consumption in Serum of Healthy Men
por: Pimentel, Grégory, et al.
Publicado: (2018)

The Plasma Proteome Is Associated with Anthropometric Status of Undernourished Nepalese School-Aged Children(1)(2)(3)
por: Lee, Sun Eun, et al.
Publicado: (2017)

Identification of Milk and Cheese Intake Biomarkers in Healthy Adults Reveals High Interindividual Variability of Lewis System–Related Oligosaccharides
por: Pimentel, Grégory, et al.
Publicado: (2020)

Treatment with Nitrate, but Not Nitrite, Lowers the Oxygen Cost of Exercise and Decreases Glycolytic Intermediates While Increasing Fatty Acid Metabolites in Exercised Zebrafish
por: Axton, Elizabeth R, et al.
Publicado: (2019)

Personalized Profiling Reveals Donor- and Lactation-Specific Trends in the Human Milk Proteome and Peptidome
por: Zhu, Jing, et al.
Publicado: (2021)

Urine Metabolite Profiles and Nutrient Intake Based on 4-Day Weighed Food Diary in Habitual Vegans, Vegetarians, and Omnivores
por: Lindqvist, Helen M, et al.
Publicado: (2020)

DHA Supplementation Attenuates Inflammation-Associated Gene Expression in the Mammary Gland of Lactating Mothers Who Deliver Preterm
por: Adams, Joselyn M, et al.
Publicado: (2022)

Plasma MicroRNA Signature of Alcohol Consumption: The Rotterdam Study
por: Karabegović, Irma, et al.
Publicado: (2022)

Haptoglobin 1-1 Genotype Modulates the Association of Glycemic Control With Hippocampal Volume in Elderly Individuals With Type 2 Diabetes
por: Livny, Abigail, et al.
Publicado: (2017)

Empty SV40 capsids increase survival of septic rats by eliciting numerous host signaling networks that participate in a number of systemic functions
por: Ben-Nun-Shaul, Orly, et al.
Publicado: (2020)

A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes
por: Mercader, Josep M., et al.
Publicado: (2017)

G(0)-G(1) Transition and the Restriction Point in Pancreatic β-Cells In Vivo
por: Hija, Ayat, et al.
Publicado: (2014)

AN1284 attenuates steatosis, lipogenesis, and fibrosis in mice with pre-existing non-alcoholic steatohepatitis and directly affects aryl hydrocarbon receptor in a hepatic cell line
por: Yehezkel, Adi S., et al.
Publicado: (2023)

Glycemic control releases regenerative potential of pancreatic beta cells blocked by severe hyperglycemia
por: Furth-Lavi, Judith, et al.
Publicado: (2022)

Deep Resequencing Unveils Genetic Architecture of ADIPOQ and Identifies a Novel Low-Frequency Variant Strongly Associated With Adiponectin Variation
por: Warren, Liling L., et al.
Publicado: (2012)

No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
por: Scott, Robert A., et al.
Publicado: (2012)

Peripheral Blood Monocyte Gene Expression Profile Clinically Stratifies Patients With Recent-Onset Type 1 Diabetes
por: Irvine, Katharine M., et al.
Publicado: (2012)

Placental Adiponectin Gene DNA Methylation Levels Are Associated With Mothers’ Blood Glucose Concentration
por: Bouchard, Luigi, et al.
Publicado: (2012)

Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations: The Population Architecture using Genomics and Epidemiology (PAGE) Consortium
por: Haiman, Christopher A., et al.
Publicado: (2012)

Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men
por: Stančáková, Alena, et al.
Publicado: (2012)

A Gene-Family Analysis of 61 Genetic Variants in the Nicotinic Acetylcholine Receptor Genes for Insulin Resistance and Type 2 Diabetes in American Indians
por: Yang, Jingyun, et al.
Publicado: (2012)

MicroRNA Dysregulation in Diabetic Ischemic Heart Failure Patients
por: Greco, Simona, et al.
Publicado: (2012)

Effect of the PTPN22 and INS Risk Genotypes on the Progression to Clinical Type 1 Diabetes After the Initiation of β-Cell Autoimmunity
por: Lempainen, Johanna, et al.
Publicado: (2012)

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression
por: Bergholdt, Regine, et al.
Publicado: (2012)

Global DNA Methylation Is Associated With Insulin Resistance: A Monozygotic Twin Study
por: Zhao, Jinying, et al.
Publicado: (2012)

Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk
por: Marquez, Marcel, et al.
Publicado: (2012)

A Genome-Wide Association Study of Gestational Diabetes Mellitus in Korean Women
por: Kwak, Soo Heon, et al.
Publicado: (2012)

Effects of Non-HLA Gene Polymorphisms on Development of Islet Autoimmunity and Type 1 Diabetes in a Population With High-Risk HLA-DR,DQ Genotypes
por: Steck, Andrea K., et al.
Publicado: (2012)

Genetic Predisposition to Dyslipidemia and Type 2 Diabetes Risk in Two Prospective Cohorts
por: Qi, Qibin, et al.
Publicado: (2012)

The ATP-Sensitive K(+) Channel ABCC8 S1369A Type 2 Diabetes Risk Variant Increases MgATPase Activity
por: Fatehi, Mohammad, et al.
Publicado: (2012)

Greater Impact of Melanocortin-4 Receptor Deficiency on Rates of Growth and Risk of Type 2 Diabetes During Childhood Compared With Adulthood in Pima Indians
por: Thearle, Marie S., et al.
Publicado: (2012)

Mitochondrial DNA Coding and Control Region Variants as Genetic Risk Factors for Type 2 Diabetes
por: Liou, Chia-Wei, et al.
Publicado: (2012)

Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits
por: Billings, Liana K., et al.
Publicado: (2012)

Changing Metabolic Signatures of Amino Acids and Lipids During the Prediabetic Period in a Pig Model With Impaired Incretin Function and Reduced β-Cell Mass
por: Renner, Simone, et al.
Publicado: (2012)

Association Testing of Previously Reported Variants in a Large Case-Control Meta-analysis of Diabetic Nephropathy
por: Williams, Winfred W., et al.
Publicado: (2012)

The Gly(972)Arg Variant of Human IRS1 Gene Is Associated With Variation in Glomerular Filtration Rate Likely Through Impaired Insulin Receptor Signaling
por: Thameem, Farook, et al.
Publicado: (2012)

Metabolite Profiling Reveals Normal Metabolic Control in Carriers of Mutations in the Glucokinase Gene (MODY2)
por: Spégel, Peter, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_qstnpq66j2rsrl644f00qt51bl