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Admixture into and within sub-Saharan Africa
Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the stru...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915815/ https://www.ncbi.nlm.nih.gov/pubmed/27324836 http://dx.doi.org/10.7554/eLife.15266 |
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author | Busby, George BJ Band, Gavin Si Le, Quang Jallow, Muminatou Bougama, Edith Mangano, Valentina D Amenga-Etego, Lucas N Enimil, Anthony Apinjoh, Tobias Ndila, Carolyne M Manjurano, Alphaxard Nyirongo, Vysaul Doumba, Ogobara Rockett, Kirk A Kwiatkowski, Dominic P Spencer, Chris CA |
author_facet | Busby, George BJ Band, Gavin Si Le, Quang Jallow, Muminatou Bougama, Edith Mangano, Valentina D Amenga-Etego, Lucas N Enimil, Anthony Apinjoh, Tobias Ndila, Carolyne M Manjurano, Alphaxard Nyirongo, Vysaul Doumba, Ogobara Rockett, Kirk A Kwiatkowski, Dominic P Spencer, Chris CA |
author_sort | Busby, George BJ |
collection | PubMed |
description | Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology. DOI: http://dx.doi.org/10.7554/eLife.15266.001 |
format | Online Article Text |
id | pubmed-4915815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-49158152016-06-23 Admixture into and within sub-Saharan Africa Busby, George BJ Band, Gavin Si Le, Quang Jallow, Muminatou Bougama, Edith Mangano, Valentina D Amenga-Etego, Lucas N Enimil, Anthony Apinjoh, Tobias Ndila, Carolyne M Manjurano, Alphaxard Nyirongo, Vysaul Doumba, Ogobara Rockett, Kirk A Kwiatkowski, Dominic P Spencer, Chris CA eLife Genomics and Evolutionary Biology Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology. DOI: http://dx.doi.org/10.7554/eLife.15266.001 eLife Sciences Publications, Ltd 2016-06-21 /pmc/articles/PMC4915815/ /pubmed/27324836 http://dx.doi.org/10.7554/eLife.15266 Text en © 2016, Busby et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Genomics and Evolutionary Biology Busby, George BJ Band, Gavin Si Le, Quang Jallow, Muminatou Bougama, Edith Mangano, Valentina D Amenga-Etego, Lucas N Enimil, Anthony Apinjoh, Tobias Ndila, Carolyne M Manjurano, Alphaxard Nyirongo, Vysaul Doumba, Ogobara Rockett, Kirk A Kwiatkowski, Dominic P Spencer, Chris CA Admixture into and within sub-Saharan Africa |
title | Admixture into and within sub-Saharan Africa |
title_full | Admixture into and within sub-Saharan Africa |
title_fullStr | Admixture into and within sub-Saharan Africa |
title_full_unstemmed | Admixture into and within sub-Saharan Africa |
title_short | Admixture into and within sub-Saharan Africa |
title_sort | admixture into and within sub-saharan africa |
topic | Genomics and Evolutionary Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915815/ https://www.ncbi.nlm.nih.gov/pubmed/27324836 http://dx.doi.org/10.7554/eLife.15266 |
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