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Admixture into and within sub-Saharan Africa

Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the stru...

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Autores principales: Busby, George BJ, Band, Gavin, Si Le, Quang, Jallow, Muminatou, Bougama, Edith, Mangano, Valentina D, Amenga-Etego, Lucas N, Enimil, Anthony, Apinjoh, Tobias, Ndila, Carolyne M, Manjurano, Alphaxard, Nyirongo, Vysaul, Doumba, Ogobara, Rockett, Kirk A, Kwiatkowski, Dominic P, Spencer, Chris CA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915815/
https://www.ncbi.nlm.nih.gov/pubmed/27324836
http://dx.doi.org/10.7554/eLife.15266
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author Busby, George BJ
Band, Gavin
Si Le, Quang
Jallow, Muminatou
Bougama, Edith
Mangano, Valentina D
Amenga-Etego, Lucas N
Enimil, Anthony
Apinjoh, Tobias
Ndila, Carolyne M
Manjurano, Alphaxard
Nyirongo, Vysaul
Doumba, Ogobara
Rockett, Kirk A
Kwiatkowski, Dominic P
Spencer, Chris CA
author_facet Busby, George BJ
Band, Gavin
Si Le, Quang
Jallow, Muminatou
Bougama, Edith
Mangano, Valentina D
Amenga-Etego, Lucas N
Enimil, Anthony
Apinjoh, Tobias
Ndila, Carolyne M
Manjurano, Alphaxard
Nyirongo, Vysaul
Doumba, Ogobara
Rockett, Kirk A
Kwiatkowski, Dominic P
Spencer, Chris CA
author_sort Busby, George BJ
collection PubMed
description Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology. DOI: http://dx.doi.org/10.7554/eLife.15266.001
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spelling pubmed-49158152016-06-23 Admixture into and within sub-Saharan Africa Busby, George BJ Band, Gavin Si Le, Quang Jallow, Muminatou Bougama, Edith Mangano, Valentina D Amenga-Etego, Lucas N Enimil, Anthony Apinjoh, Tobias Ndila, Carolyne M Manjurano, Alphaxard Nyirongo, Vysaul Doumba, Ogobara Rockett, Kirk A Kwiatkowski, Dominic P Spencer, Chris CA eLife Genomics and Evolutionary Biology Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology. DOI: http://dx.doi.org/10.7554/eLife.15266.001 eLife Sciences Publications, Ltd 2016-06-21 /pmc/articles/PMC4915815/ /pubmed/27324836 http://dx.doi.org/10.7554/eLife.15266 Text en © 2016, Busby et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Genomics and Evolutionary Biology
Busby, George BJ
Band, Gavin
Si Le, Quang
Jallow, Muminatou
Bougama, Edith
Mangano, Valentina D
Amenga-Etego, Lucas N
Enimil, Anthony
Apinjoh, Tobias
Ndila, Carolyne M
Manjurano, Alphaxard
Nyirongo, Vysaul
Doumba, Ogobara
Rockett, Kirk A
Kwiatkowski, Dominic P
Spencer, Chris CA
Admixture into and within sub-Saharan Africa
title Admixture into and within sub-Saharan Africa
title_full Admixture into and within sub-Saharan Africa
title_fullStr Admixture into and within sub-Saharan Africa
title_full_unstemmed Admixture into and within sub-Saharan Africa
title_short Admixture into and within sub-Saharan Africa
title_sort admixture into and within sub-saharan africa
topic Genomics and Evolutionary Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915815/
https://www.ncbi.nlm.nih.gov/pubmed/27324836
http://dx.doi.org/10.7554/eLife.15266
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