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A TRAF-like motif of ICOS controls development of germinal center T follicular helper cells via TBK1

Inducible costimulator (ICOS) signaling fuels the stepwise development of T follicular helper (T(FH)) cells. However, a signaling pathway unique to ICOS has not been identified. We show that TANK-binding kinase 1 (TBK1) associates with ICOS via a conserved motif, IProx, which shares homology with tu...

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Detalles Bibliográficos
Autores principales:	Pedros, Christophe, Zhang, Yaoyang, Hu, Joyce K., Choi, Youn Soo, Canonigo-Balancio, Ann J, Yates, John R., Altman, Amnon, Crotty, Shane, Kong, Kok-Fai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915981/ https://www.ncbi.nlm.nih.gov/pubmed/27135603 http://dx.doi.org/10.1038/ni.3463

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