Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol

Most adaptive immune responses require the activation of specific T cells through the T cell antigen receptor–CD3 complex (TCR). Here we show that cholesterol sulfate (CS), a naturally occurring analog of cholesterol, inhibits CD3 ITAM phosphorylation, a crucial first step in T cell activation. Bioc...

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Detalles Bibliográficos
Autores principales: Wang, Feng, Beck-García, Katharina, Zorzin, Carina, Schamel, Wolfgang W. A., Davis, Mark M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916016/
https://www.ncbi.nlm.nih.gov/pubmed/27213689
http://dx.doi.org/10.1038/ni.3462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916016/
https://www.ncbi.nlm.nih.gov/pubmed/27213689
http://dx.doi.org/10.1038/ni.3462

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