Tumor suppressor NFκB2 p100 interacts with ERK2 and stabilizes PTEN mRNA via inhibition of miR-494

Emerging evidence from The Cancer Genome Atlas (TCGA) has revealed that nfκb2 gene encoding p100 is genetically deleted or mutated in human cancers, implicating NFκB2 as a potential tumor suppressor. However, the molecular mechanism underlying the anti-tumorigenic action of p100 remains poorly under...

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Detalles Bibliográficos
Autores principales: Wang, Yulei, Xu, Jiawei, Gao, Guangxun, Li, Jingxia, Huang, Haishan, Jin, Honglei, Zhu, Junlan, Che, Xun, Huang, Chuanshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916044/
https://www.ncbi.nlm.nih.gov/pubmed/26686085
http://dx.doi.org/10.1038/onc.2015.470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916044/
https://www.ncbi.nlm.nih.gov/pubmed/26686085
http://dx.doi.org/10.1038/onc.2015.470

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