Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen

INTRODUCTION: Acetaminophen (paracetamol) is mainly metabolized via glucuronidation and sulphation, while the minor pathway through cytochrome P450 (CYP) 2E1 is held responsible for hepatotoxicity. In obese patients, CYP2E1 activity is reported to be induced, thereby potentially worsening the safety...

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Detalles Bibliográficos
Autores principales: van Rongen, Anne, Välitalo, Pyry A. J., Peeters, Mariska Y. M., Boerma, Djamila, Huisman, Fokko W., van Ramshorst, Bert, van Dongen, Eric P. A., van den Anker, Johannes N., Knibbe, Catherijne A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916199/
https://www.ncbi.nlm.nih.gov/pubmed/26818482
http://dx.doi.org/10.1007/s40262-015-0357-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916199/
https://www.ncbi.nlm.nih.gov/pubmed/26818482
http://dx.doi.org/10.1007/s40262-015-0357-0

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