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Molecular Background of miRNA Role in Asthma and COPD: An Updated Insight

Inflammatory airway diseases are a significant health problems requiring new approaches to the existing therapies and addressing fundamental issues. Difficulties in developing effective therapeutic strategies might be caused by lack of understanding of their exact molecular mechanism. MicroRNAs (miR...

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Detalles Bibliográficos
Autores principales: Szymczak, Izabela, Wieczfinska, Joanna, Pawliczak, Rafal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916273/
https://www.ncbi.nlm.nih.gov/pubmed/27376086
http://dx.doi.org/10.1155/2016/7802521
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author Szymczak, Izabela
Wieczfinska, Joanna
Pawliczak, Rafal
author_facet Szymczak, Izabela
Wieczfinska, Joanna
Pawliczak, Rafal
author_sort Szymczak, Izabela
collection PubMed
description Inflammatory airway diseases are a significant health problems requiring new approaches to the existing therapies and addressing fundamental issues. Difficulties in developing effective therapeutic strategies might be caused by lack of understanding of their exact molecular mechanism. MicroRNAs (miRNAs) are a class of regulators that already revolutionized the view of gene expression regulation. A cumulating number of investigations show a pivotal role of miRNAs in the pathogenesis of asthma, chronic obstructive pulmonary disease (COPD), or airway remodeling through the regulation of many pathways involved in their pathogenesis. Expression changes of several miRNAs have also been found to play a role in the development and/or improvement in asthma or COPD. Still, relatively little is known about the role of miRNAs in inflammatory disorders. The microRNA profiles may differ depending on the cell type or antigen-presenting cell. Based on the newest literature, this review discusses the current knowledge concerning miRNA contribution and influence on lung inflammation and chosen inflammatory airway diseases: asthma and COPD.
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spelling pubmed-49162732016-07-03 Molecular Background of miRNA Role in Asthma and COPD: An Updated Insight Szymczak, Izabela Wieczfinska, Joanna Pawliczak, Rafal Biomed Res Int Review Article Inflammatory airway diseases are a significant health problems requiring new approaches to the existing therapies and addressing fundamental issues. Difficulties in developing effective therapeutic strategies might be caused by lack of understanding of their exact molecular mechanism. MicroRNAs (miRNAs) are a class of regulators that already revolutionized the view of gene expression regulation. A cumulating number of investigations show a pivotal role of miRNAs in the pathogenesis of asthma, chronic obstructive pulmonary disease (COPD), or airway remodeling through the regulation of many pathways involved in their pathogenesis. Expression changes of several miRNAs have also been found to play a role in the development and/or improvement in asthma or COPD. Still, relatively little is known about the role of miRNAs in inflammatory disorders. The microRNA profiles may differ depending on the cell type or antigen-presenting cell. Based on the newest literature, this review discusses the current knowledge concerning miRNA contribution and influence on lung inflammation and chosen inflammatory airway diseases: asthma and COPD. Hindawi Publishing Corporation 2016 2016-06-08 /pmc/articles/PMC4916273/ /pubmed/27376086 http://dx.doi.org/10.1155/2016/7802521 Text en Copyright © 2016 Izabela Szymczak et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Szymczak, Izabela
Wieczfinska, Joanna
Pawliczak, Rafal
Molecular Background of miRNA Role in Asthma and COPD: An Updated Insight
title Molecular Background of miRNA Role in Asthma and COPD: An Updated Insight
title_full Molecular Background of miRNA Role in Asthma and COPD: An Updated Insight
title_fullStr Molecular Background of miRNA Role in Asthma and COPD: An Updated Insight
title_full_unstemmed Molecular Background of miRNA Role in Asthma and COPD: An Updated Insight
title_short Molecular Background of miRNA Role in Asthma and COPD: An Updated Insight
title_sort molecular background of mirna role in asthma and copd: an updated insight
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916273/
https://www.ncbi.nlm.nih.gov/pubmed/27376086
http://dx.doi.org/10.1155/2016/7802521
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