Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice

Increasing evidence suggests that oxidative DNA damage accumulates in atherosclerosis. Recently, we showed that a genetic variant in the human DNA repair enzyme NEIL3 was associated with increased risk of myocardial infarction. Here, we explored the role of Neil3/NEIL3 in atherogenesis by both clini...

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Detalles Bibliográficos
Autores principales: Skarpengland, Tonje, Holm, Sverre, Scheffler, Katja, Gregersen, Ida, Dahl, Tuva B., Suganthan, Rajikala, Segers, Filip M., Østlie, Ingunn, Otten, Jeroen J. T., Luna, Luisa, Ketelhuth, Daniel F. J., Lundberg, Anna M., Neurauter, Christine G., Hildrestrand, Gunn, Skjelland, Mona, Bjørndal, Bodil, Svardal, Asbjørn M., Iversen, Per O., Hedin, Ulf, Nygård, Ståle, Olstad, Ole K., Krohg-Sørensen, Kirsten, Slupphaug, Geir, Eide, Lars, Kuśnierczyk, Anna, Folkersen, Lasse, Ueland, Thor, Berge, Rolf K., Hansson, Göran K., Biessen, Erik A. L., Halvorsen, Bente, Bjørås, Magnar, Aukrust, Pål
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916448/
https://www.ncbi.nlm.nih.gov/pubmed/27328939
http://dx.doi.org/10.1038/srep28337

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