Cargando…
Ketoacidosis at first presentation of type 1 diabetes mellitus among children: a study from Kuwait
We examined the frequency and severity of diabetic ketoacidosis (DKA) in 679 children and adolescents (0–14 years) at diagnosis of Type 1 Diabetes Mellitus (T1DM) in Kuwait. Between 1(st) January 2011 and 31(st) December 2013, all newly diagnosed children with diabetes were registered prospectively...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916451/ https://www.ncbi.nlm.nih.gov/pubmed/27328757 http://dx.doi.org/10.1038/srep27519 |
_version_ | 1782438833930895360 |
---|---|
author | Shaltout, Azza Aly Channanath, Arshad Mohamed Thanaraj, Thangavel Alphonse Omar, Dina Abdulrasoul, Majedah Zanaty, Nabila Almahdi, Maria Alkandari, Hessa AlAbdulrazzaq, Dalia d’Mello, Linda Mandani, Fawziya Alanezi, Ayed AlBasiry, Eman Alkhawari, M. |
author_facet | Shaltout, Azza Aly Channanath, Arshad Mohamed Thanaraj, Thangavel Alphonse Omar, Dina Abdulrasoul, Majedah Zanaty, Nabila Almahdi, Maria Alkandari, Hessa AlAbdulrazzaq, Dalia d’Mello, Linda Mandani, Fawziya Alanezi, Ayed AlBasiry, Eman Alkhawari, M. |
author_sort | Shaltout, Azza Aly |
collection | PubMed |
description | We examined the frequency and severity of diabetic ketoacidosis (DKA) in 679 children and adolescents (0–14 years) at diagnosis of Type 1 Diabetes Mellitus (T1DM) in Kuwait. Between 1(st) January 2011 and 31(st) December 2013, all newly diagnosed children with diabetes were registered prospectively in a population-based electronic register. DKA was diagnosed using standard criteria based on the levels of venous pH and serum bicarbonate. At the time of diagnosis, mild/moderate DKA was present in 24.8% of the children, while severe DKA was present in 8.8%. Incidence of ketoacidosis was significantly higher in young children less than 2 (60.7% vs 32.4% p = <0.005) compared to children 2–14 years old, and a higher proportion presented with severe DKA (21.4% vs 8.3% p = <0.05). No association was seen with gender. Significant differences were found in the incidence of DKA between Kuwaiti and non-Kuwaiti children (31.1% vs 39.8%; p < 0.05). Family history of diabetes had a protective effect on the occurrence of DKA (OR = 0.44; 95% CI = 0.27–0.71). Incidence of DKA in children at presentation of T1DM remains high at 33.6%. Prevention campaigns are needed to increase public awareness among health care providers, parents and school teachers in Kuwait. |
format | Online Article Text |
id | pubmed-4916451 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49164512016-06-27 Ketoacidosis at first presentation of type 1 diabetes mellitus among children: a study from Kuwait Shaltout, Azza Aly Channanath, Arshad Mohamed Thanaraj, Thangavel Alphonse Omar, Dina Abdulrasoul, Majedah Zanaty, Nabila Almahdi, Maria Alkandari, Hessa AlAbdulrazzaq, Dalia d’Mello, Linda Mandani, Fawziya Alanezi, Ayed AlBasiry, Eman Alkhawari, M. Sci Rep Article We examined the frequency and severity of diabetic ketoacidosis (DKA) in 679 children and adolescents (0–14 years) at diagnosis of Type 1 Diabetes Mellitus (T1DM) in Kuwait. Between 1(st) January 2011 and 31(st) December 2013, all newly diagnosed children with diabetes were registered prospectively in a population-based electronic register. DKA was diagnosed using standard criteria based on the levels of venous pH and serum bicarbonate. At the time of diagnosis, mild/moderate DKA was present in 24.8% of the children, while severe DKA was present in 8.8%. Incidence of ketoacidosis was significantly higher in young children less than 2 (60.7% vs 32.4% p = <0.005) compared to children 2–14 years old, and a higher proportion presented with severe DKA (21.4% vs 8.3% p = <0.05). No association was seen with gender. Significant differences were found in the incidence of DKA between Kuwaiti and non-Kuwaiti children (31.1% vs 39.8%; p < 0.05). Family history of diabetes had a protective effect on the occurrence of DKA (OR = 0.44; 95% CI = 0.27–0.71). Incidence of DKA in children at presentation of T1DM remains high at 33.6%. Prevention campaigns are needed to increase public awareness among health care providers, parents and school teachers in Kuwait. Nature Publishing Group 2016-06-22 /pmc/articles/PMC4916451/ /pubmed/27328757 http://dx.doi.org/10.1038/srep27519 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Shaltout, Azza Aly Channanath, Arshad Mohamed Thanaraj, Thangavel Alphonse Omar, Dina Abdulrasoul, Majedah Zanaty, Nabila Almahdi, Maria Alkandari, Hessa AlAbdulrazzaq, Dalia d’Mello, Linda Mandani, Fawziya Alanezi, Ayed AlBasiry, Eman Alkhawari, M. Ketoacidosis at first presentation of type 1 diabetes mellitus among children: a study from Kuwait |
title | Ketoacidosis at first presentation of type 1 diabetes mellitus among children: a study from Kuwait |
title_full | Ketoacidosis at first presentation of type 1 diabetes mellitus among children: a study from Kuwait |
title_fullStr | Ketoacidosis at first presentation of type 1 diabetes mellitus among children: a study from Kuwait |
title_full_unstemmed | Ketoacidosis at first presentation of type 1 diabetes mellitus among children: a study from Kuwait |
title_short | Ketoacidosis at first presentation of type 1 diabetes mellitus among children: a study from Kuwait |
title_sort | ketoacidosis at first presentation of type 1 diabetes mellitus among children: a study from kuwait |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916451/ https://www.ncbi.nlm.nih.gov/pubmed/27328757 http://dx.doi.org/10.1038/srep27519 |
work_keys_str_mv | AT shaltoutazzaaly ketoacidosisatfirstpresentationoftype1diabetesmellitusamongchildrenastudyfromkuwait AT channanatharshadmohamed ketoacidosisatfirstpresentationoftype1diabetesmellitusamongchildrenastudyfromkuwait AT thanarajthangavelalphonse ketoacidosisatfirstpresentationoftype1diabetesmellitusamongchildrenastudyfromkuwait AT omardina ketoacidosisatfirstpresentationoftype1diabetesmellitusamongchildrenastudyfromkuwait AT abdulrasoulmajedah ketoacidosisatfirstpresentationoftype1diabetesmellitusamongchildrenastudyfromkuwait AT zanatynabila ketoacidosisatfirstpresentationoftype1diabetesmellitusamongchildrenastudyfromkuwait AT almahdimaria ketoacidosisatfirstpresentationoftype1diabetesmellitusamongchildrenastudyfromkuwait AT alkandarihessa ketoacidosisatfirstpresentationoftype1diabetesmellitusamongchildrenastudyfromkuwait AT alabdulrazzaqdalia ketoacidosisatfirstpresentationoftype1diabetesmellitusamongchildrenastudyfromkuwait AT dmellolinda ketoacidosisatfirstpresentationoftype1diabetesmellitusamongchildrenastudyfromkuwait AT mandanifawziya ketoacidosisatfirstpresentationoftype1diabetesmellitusamongchildrenastudyfromkuwait AT alaneziayed ketoacidosisatfirstpresentationoftype1diabetesmellitusamongchildrenastudyfromkuwait AT albasiryeman ketoacidosisatfirstpresentationoftype1diabetesmellitusamongchildrenastudyfromkuwait AT alkhawarim ketoacidosisatfirstpresentationoftype1diabetesmellitusamongchildrenastudyfromkuwait |