Cargando…
Comprehensive Vibrational Spectroscopic Investigation of trans,trans,trans-[Pt(N(3))(2)(OH)(2)(py)(2)], a Pt(IV) Diazido Anticancer Prodrug Candidate
[Image: see text] We report a detailed study of a promising photoactivatable metal-based anticancer prodrug candidate, trans,trans,trans-[Pt(N(3))(2)(OH)(2)(py)(2)] (C1; py = pyridine), using vibrational spectroscopic techniques. Attenuated total reflection Fourier transform infrared (ATR-FTIR), Ram...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2016
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916484/ https://www.ncbi.nlm.nih.gov/pubmed/27257848 http://dx.doi.org/10.1021/acs.inorgchem.6b00476 |
Sumario: | [Image: see text] We report a detailed study of a promising photoactivatable metal-based anticancer prodrug candidate, trans,trans,trans-[Pt(N(3))(2)(OH)(2)(py)(2)] (C1; py = pyridine), using vibrational spectroscopic techniques. Attenuated total reflection Fourier transform infrared (ATR-FTIR), Raman, and synchrotron radiation far-IR (SR-FIR) spectroscopies were applied to obtain highly resolved ligand and Pt-ligand vibrations for C1 and its precursors (trans-[Pt(N(3))(2)(py)(2)] (C2) and trans-[PtCl(2)(py)(2)] (C3)). Distinct IR- and Raman-active vibrational modes were assigned with the aid of density functional theory calculations, and trends in the frequency shifts as a function of changing Pt coordination environment were determined and detailed for the first time. The data provide the ligand and Pt-ligand (azide, hydroxide, pyridine) vibrational signatures for C1 in the mid- and far-IR region, which will provide a basis for the better understanding of the interaction of C1 with biomolecules. |
---|