The spectrum effect in tests for risk prediction, screening, and diagnosis

The spectrum effect describes the variation between settings in performance of tests used to predict, screen for, and diagnose disease. In particular, the predictive use of a test may be different when it is applied in a general population rather than in the study sample in which it was first develo...

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Detalles Bibliográficos
Autores principales: Usher-Smith, Juliet A, Sharp,, Stephen J, Griffin, Simon J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group Ltd. 2016
Materias:
Research Methods & Reporting
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916916/
https://www.ncbi.nlm.nih.gov/pubmed/27334281
http://dx.doi.org/10.1136/bmj.i3139
Descripción
Sumario:The spectrum effect describes the variation between settings in performance of tests used to predict, screen for, and diagnose disease. In particular, the predictive use of a test may be different when it is applied in a general population rather than in the study sample in which it was first developed. This article discusses the impact of the spectrum effect on measures of test performance, and its implications for the development, evaluation, application, and implementation of such tests.

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