Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies

Outbreaks of acute gastroenteritis caused by noroviruses constitute a public health concern worldwide. To date, there are no approved drugs or vaccines for the management and prophylaxis of norovirus infections. A potentially effective strategy for the development of norovirus therapeutics entails t...

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Detalles Bibliográficos
Autores principales: Weerawarna, Pathum M., Kim, Yunjeong, Galasiti Kankanamalage, Anushka C., Damalanka, Vishnu C., Lushington, Gerald H., Alliston, Kevin R., Mehzabeen, Nurjahan, Battaile, Kevin P., Lovell, Scott, Chang, Kyeong-Ok, Groutas, William C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editions Scientifiques Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916972/
https://www.ncbi.nlm.nih.gov/pubmed/27235842
http://dx.doi.org/10.1016/j.ejmech.2016.04.013

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