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ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain

The human redox-sensitive Transient receptor potential melastatin type 2 (hTRPM2) channel contains the C-terminal Nudix hydrolase domain NUDT9H which most likely binds ADP-ribose. During oxidative stress, the intracellular release of ADP-ribose triggers the activation of hTRPM2. The TRPM2 orthologue...

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Detalles Bibliográficos
Autores principales:	Kühn, Frank J. P., Kühn, Cornelia, Winking, Mathis, Hoffmann, Daniel C., Lückhoff, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917252/ https://www.ncbi.nlm.nih.gov/pubmed/27333281 http://dx.doi.org/10.1371/journal.pone.0158060

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