Cargando…

Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABA(A) Receptors: Functional Characteristics and Molecular Mechanism

Extracts of the pepper plant kava (Piper methysticum) are effective in alleviating anxiety in clinical trials. Despite the long-standing therapeutic interest in kava, the molecular target(s) of the pharmacologically active constituents, kavalactones have not been established. γ-Aminobutyric acid typ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chua, Han Chow, Christensen, Emilie T. H., Hoestgaard-Jensen, Kirsten, Hartiadi, Leonny Y., Ramzan, Iqbal, Jensen, Anders A., Absalom, Nathan L., Chebib, Mary
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917254/ https://www.ncbi.nlm.nih.gov/pubmed/27332705 http://dx.doi.org/10.1371/journal.pone.0157700

Ejemplares similares

Toxicokinetics of Kava
por: Rowe, Anthony, et al.
Publicado: (2011)

GABA-A Receptor Modulation and Anticonvulsant, Anxiolytic, and Antidepressant Activities of Constituents from Artemisia indica Linn
por: Khan, Imran, et al.
Publicado: (2016)

The Direct Actions of GABA, 2’-Methoxy-6-Methylflavone and General Anaesthetics at β3γ2L GABA(A) Receptors: Evidence for Receptors with Different Subunit Stoichiometries
por: Chua, Han Chow, et al.
Publicado: (2015)

Kava-Kava in Gonorrhœa
Publicado: (1893)

Kava, Kawa, Kava-Kava—A Powerful Anæsthetic and Spinal Depressant
Publicado: (1886)

Identification of a Kavain Analog with Efficient Anti-inflammatory Effects
por: Huck, Olivier, et al.
Publicado: (2019)

Cases of Genito-Urinary Diseases Treated by Kava-Kava
por: Phillips, Leslie
Publicado: (1897)

Inflammatory sebotropic reaction associated with kava kava ingestion
por: Brown-Joel, Zoe O., et al.
Publicado: (2018)

Kava : the Pacific drug /
por: Lebot, Vincent
Publicado: (1992)

Kavain suppresses human Aβ-induced paralysis in C. elegans
por: Chamoli, Manish, et al.
Publicado: (2020)

Kava constituents exert selective anticancer effects in oral squamous cell carcinoma cells in vitro
por: Celentano, Antonio, et al.
Publicado: (2020)

Neuroimaging Insights: Kava’s (Piper methysticum) Effect on Dorsal Anterior Cingulate Cortex GABA in Generalized Anxiety Disorder
por: Savage, Karen, et al.
Publicado: (2023)

Estimation of Apigenin, an Anxiolytic Constituent, in Turnera aphrodisiaca
por: Kumar, S., et al.
Publicado: (2008)

The GABA(A)-Benzodiazepine Receptor Antagonist Flumazenil Abolishes the Anxiolytic Effects of the Active Constituents of Crocus sativus L. Crocins in Rats
por: Pitsikas, Nikolaos, et al.
Publicado: (2020)

Kava as a Clinical Nutrient: Promises and Challenges
por: Bian, Tengfei, et al.
Publicado: (2020)

Opportunities and Challenges of Kava in Lung Cancer Prevention
por: Freeman, Breanne, et al.
Publicado: (2023)

Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond
por: Zorumski, Charles F., et al.
Publicado: (2019)

Involvement of GABA(A) Receptors in the Anxiolytic-Like Effect of Hydroxycitronellal
por: Andrade, Jéssica C., et al.
Publicado: (2021)

Anxiolytics for Bronchodilation: Refinements to GABA(A) Agonists for Asthma Relief
por: Nayak, Ajay P., et al.
Publicado: (2022)

Investigating the Role of Loop C Hydrophilic Residue ‘T244’ in the Binding Site of ρ1 GABA(C) Receptors via Site Mutation and Partial Agonism
por: Naffaa, Moawiah M., et al.
Publicado: (2016)

Hepatotoxicity Induced by “the 3Ks”: Kava, Kratom and Khat
por: Pantano, Flaminia, et al.
Publicado: (2016)

An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava
por: Soares, Rita B., et al.
Publicado: (2022)

Enhanced efficacy and reduced side effects of diazepam by kava combination
por: Tawfiq, Rasha A., et al.
Publicado: (2014)

Zolpidem is a potent stoichiometry-selective modulator of α1β3 GABA(A) receptors: evidence of a novel benzodiazepine site in the α1-α1 interface
por: Che Has, Ahmad Tarmizi, et al.
Publicado: (2016)

Anxiolytic-like Effect of Testosterone in Male Rats: GABA(C) Receptors Are Not Involved
por: Roohbakhsh, Ali, et al.
Publicado: (2011)

Pharmacological Effect of GABA Analogues on GABA-ρ2 Receptors and Their Subtype Selectivity
por: Naffaa, Moawiah M., et al.
Publicado: (2022)

Kava-induced acute cutaneous toxicity: An increasingly recognized characteristic clinicohistologic pattern
por: Rzepecki, Alexandra K., et al.
Publicado: (2018)

Identification of GABA receptors in chick cornea
por: Cheng, Zhen-Ying, et al.
Publicado: (2012)

Participation of GABA(A) Chloride Channels in the Anxiolytic-Like Effects of a Fatty Acid Mixture
por: Rodríguez-Landa, Juan Francisco, et al.
Publicado: (2013)

GABA and 5-HT Systems Are Involved in the Anxiolytic Effect of Gan-Mai-Da-Zao Decoction
por: Chen, Hong-Shu, et al.
Publicado: (2019)

Measuring the Chemical and Cytotoxic Variability of Commercially Available Kava (Piper methysticum G. Forster)
por: Martin, Amanda C., et al.
Publicado: (2014)

The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA
por: Kangarlu-Haghighi, Katayoon, et al.
Publicado: (2015)

Anxiolytic-like Effect of Quercetin Possibly through GABA Receptor Interaction Pathway: In Vivo and In Silico Studies
por: Islam, Md. Shahazul, et al.
Publicado: (2022)

A UHPLC-UV Method Development and Validation for Determining Kavalactones and Flavokavains in Piper methysticum (Kava)
por: Tang, Yijin, et al.
Publicado: (2019)

Ex vivo and in vitro inhibitory potential of Kava extract on monoamine oxidase B activity in mice
por: Krum, Bárbara Nunes, et al.
Publicado: (2021)

An update on the anxiolytic and neuroprotective properties of etifoxine: from brain GABA modulation to a whole-body mode of action
por: Nuss, Philippe, et al.
Publicado: (2019)

Anxiolytic effect of Korean Red Ginseng through upregulation of serotonin and GABA transmission and BDNF expression in immobilized mice
por: Bui, Bich Phuong, et al.
Publicado: (2022)

The anxiolytic effects of preoperative administration of pregabalin in comparison to diazepam and placebo
por: Nimmaanrat, Sasikaan, et al.
Publicado: (2023)

Kava for the treatment of generalised anxiety disorder (K-GAD): study protocol for a randomised controlled trial
por: Savage, Karen M., et al.
Publicado: (2015)

Evaluation of Anti-Convulsive Properties of Aqueous Kava Extract on Zebrafish Using the PTZ-Induced Seizure Model
por: Jaiswal, Yogini, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9h30smv8prno9qrk16m6trv4uf