Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2

[Image: see text] Protein lysine methyltransferases have recently emerged as a new target class for the development of inhibitors that modulate gene transcription or signaling pathways. SET and MYND domain containing protein 2 (SMYD2) is a catalytic SET domain containing methyltransferase reported t...

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Detalles Bibliográficos
Autores principales: Eggert, Erik, Hillig, Roman C., Koehr, Silke, Stöckigt, Detlef, Weiske, Jörg, Barak, Naomi, Mowat, Jeffrey, Brumby, Thomas, Christ, Clara D., ter Laak, Antonius, Lang, Tina, Fernandez-Montalvan, Amaury E., Badock, Volker, Weinmann, Hilmar, Hartung, Ingo V., Barsyte-Lovejoy, Dalia, Szewczyk, Magdalena, Kennedy, Steven, Li, Fengling, Vedadi, Masoud, Brown, Peter J., Santhakumar, Vijayaratnam, Arrowsmith, Cheryl H., Stellfeld, Timo, Stresemann, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917279/
https://www.ncbi.nlm.nih.gov/pubmed/27075367
http://dx.doi.org/10.1021/acs.jmedchem.5b01890

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