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Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses
Two zoonotic coronaviruses (CoVs)—SARS-CoV and MERS-CoV—have crossed species to cause severe human respiratory disease. Here, we showed that induction of airway memory CD4(+) T cells specific for a conserved epitope shared by SARS-CoV and MERS-CoV is a potential strategy for developing pan-coronavir...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917442/ https://www.ncbi.nlm.nih.gov/pubmed/27287409 http://dx.doi.org/10.1016/j.immuni.2016.05.006 |
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author | Zhao, Jincun Zhao, Jingxian Mangalam, Ashutosh K. Channappanavar, Rudragouda Fett, Craig Meyerholz, David K. Agnihothram, Sudhakar Baric, Ralph S. David, Chella S. Perlman, Stanley |
author_facet | Zhao, Jincun Zhao, Jingxian Mangalam, Ashutosh K. Channappanavar, Rudragouda Fett, Craig Meyerholz, David K. Agnihothram, Sudhakar Baric, Ralph S. David, Chella S. Perlman, Stanley |
author_sort | Zhao, Jincun |
collection | PubMed |
description | Two zoonotic coronaviruses (CoVs)—SARS-CoV and MERS-CoV—have crossed species to cause severe human respiratory disease. Here, we showed that induction of airway memory CD4(+) T cells specific for a conserved epitope shared by SARS-CoV and MERS-CoV is a potential strategy for developing pan-coronavirus vaccines. Airway memory CD4(+) T cells differed phenotypically and functionally from lung-derived cells and were crucial for protection against both CoVs in mice. Protection was dependent on interferon-γ and required early induction of robust innate and virus-specific CD8(+) T cell responses. The conserved epitope was also recognized in SARS-CoV- and MERS-CoV-infected human leukocyte antigen DR2 and DR3 transgenic mice, indicating potential relevance in human populations. Additionally, this epitope was cross-protective between human and bat CoVs, the progenitors for many human CoVs. Vaccine strategies that induce airway memory CD4(+) T cells targeting conserved epitopes might have broad applicability in the context of new CoVs and other respiratory virus outbreaks. |
format | Online Article Text |
id | pubmed-4917442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-49174422017-06-21 Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses Zhao, Jincun Zhao, Jingxian Mangalam, Ashutosh K. Channappanavar, Rudragouda Fett, Craig Meyerholz, David K. Agnihothram, Sudhakar Baric, Ralph S. David, Chella S. Perlman, Stanley Immunity Article Two zoonotic coronaviruses (CoVs)—SARS-CoV and MERS-CoV—have crossed species to cause severe human respiratory disease. Here, we showed that induction of airway memory CD4(+) T cells specific for a conserved epitope shared by SARS-CoV and MERS-CoV is a potential strategy for developing pan-coronavirus vaccines. Airway memory CD4(+) T cells differed phenotypically and functionally from lung-derived cells and were crucial for protection against both CoVs in mice. Protection was dependent on interferon-γ and required early induction of robust innate and virus-specific CD8(+) T cell responses. The conserved epitope was also recognized in SARS-CoV- and MERS-CoV-infected human leukocyte antigen DR2 and DR3 transgenic mice, indicating potential relevance in human populations. Additionally, this epitope was cross-protective between human and bat CoVs, the progenitors for many human CoVs. Vaccine strategies that induce airway memory CD4(+) T cells targeting conserved epitopes might have broad applicability in the context of new CoVs and other respiratory virus outbreaks. Elsevier Inc. 2016-06-21 2016-06-07 /pmc/articles/PMC4917442/ /pubmed/27287409 http://dx.doi.org/10.1016/j.immuni.2016.05.006 Text en © 2016 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Zhao, Jincun Zhao, Jingxian Mangalam, Ashutosh K. Channappanavar, Rudragouda Fett, Craig Meyerholz, David K. Agnihothram, Sudhakar Baric, Ralph S. David, Chella S. Perlman, Stanley Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses |
title | Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses |
title_full | Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses |
title_fullStr | Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses |
title_full_unstemmed | Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses |
title_short | Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses |
title_sort | airway memory cd4(+) t cells mediate protective immunity against emerging respiratory coronaviruses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917442/ https://www.ncbi.nlm.nih.gov/pubmed/27287409 http://dx.doi.org/10.1016/j.immuni.2016.05.006 |
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