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Marked improvement in febrile infection-related epilepsy syndrome after lidocaine plus MgSO(4) treatment in a 12-year-old girl
PURPOSE: This report sheds light on a successful treatment in febrile infection-related epilepsy syndrome (FIRES) with the combined use of lidocaine and MgSO(4). METHODS: We report a 12-year-old previously healthy girl who experienced an upper respiratory infection with fever and headache for 2 days...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917485/ https://www.ncbi.nlm.nih.gov/pubmed/27358770 http://dx.doi.org/10.1016/j.ebcr.2016.05.002 |
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author | Chou, I-Ching Lai, Huan-Cheng Tsai, Fuu-Jen Chang, Yu-Tzu Lin, Sheng-Shing Hong, Syuan-Yu Lee, Inn-Chi |
author_facet | Chou, I-Ching Lai, Huan-Cheng Tsai, Fuu-Jen Chang, Yu-Tzu Lin, Sheng-Shing Hong, Syuan-Yu Lee, Inn-Chi |
author_sort | Chou, I-Ching |
collection | PubMed |
description | PURPOSE: This report sheds light on a successful treatment in febrile infection-related epilepsy syndrome (FIRES) with the combined use of lidocaine and MgSO(4). METHODS: We report a 12-year-old previously healthy girl who experienced an upper respiratory infection with fever and headache for 2 days, then suddenly went into a coma followed by repetitive status epilepticus. All tests for CNS infection, metabolic and toxic diseases, and autoimmune encephalitis were negative. Hence, the diagnosis of FIRES was made. During 5 weeks of hospital treatment, various antiepileptic drugs were administered at different times without success. To achieve seizure control, we then attempted the use of lidocaine first, then followed by MgSO(4). RESULTS: The SE was successfully controlled when lidocaine plus MgSO(4) was introduced. At follow-up, almost no neurological sequelae remained. CONCLUSION: This is the first report describing the combined use of lidocaine and MgSO(4) with successful treatment outcomes. This experience has indicated that even FIRES can be controlled if treated promptly with certain agents. However, more studies are needed to explore the mechanisms and effects of lidocaine and MgSO(4) in FIRES. |
format | Online Article Text |
id | pubmed-4917485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-49174852016-06-29 Marked improvement in febrile infection-related epilepsy syndrome after lidocaine plus MgSO(4) treatment in a 12-year-old girl Chou, I-Ching Lai, Huan-Cheng Tsai, Fuu-Jen Chang, Yu-Tzu Lin, Sheng-Shing Hong, Syuan-Yu Lee, Inn-Chi Epilepsy Behav Case Rep Case Report PURPOSE: This report sheds light on a successful treatment in febrile infection-related epilepsy syndrome (FIRES) with the combined use of lidocaine and MgSO(4). METHODS: We report a 12-year-old previously healthy girl who experienced an upper respiratory infection with fever and headache for 2 days, then suddenly went into a coma followed by repetitive status epilepticus. All tests for CNS infection, metabolic and toxic diseases, and autoimmune encephalitis were negative. Hence, the diagnosis of FIRES was made. During 5 weeks of hospital treatment, various antiepileptic drugs were administered at different times without success. To achieve seizure control, we then attempted the use of lidocaine first, then followed by MgSO(4). RESULTS: The SE was successfully controlled when lidocaine plus MgSO(4) was introduced. At follow-up, almost no neurological sequelae remained. CONCLUSION: This is the first report describing the combined use of lidocaine and MgSO(4) with successful treatment outcomes. This experience has indicated that even FIRES can be controlled if treated promptly with certain agents. However, more studies are needed to explore the mechanisms and effects of lidocaine and MgSO(4) in FIRES. Elsevier 2016-06-02 /pmc/articles/PMC4917485/ /pubmed/27358770 http://dx.doi.org/10.1016/j.ebcr.2016.05.002 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Chou, I-Ching Lai, Huan-Cheng Tsai, Fuu-Jen Chang, Yu-Tzu Lin, Sheng-Shing Hong, Syuan-Yu Lee, Inn-Chi Marked improvement in febrile infection-related epilepsy syndrome after lidocaine plus MgSO(4) treatment in a 12-year-old girl |
title | Marked improvement in febrile infection-related epilepsy syndrome after lidocaine plus MgSO(4) treatment in a 12-year-old girl |
title_full | Marked improvement in febrile infection-related epilepsy syndrome after lidocaine plus MgSO(4) treatment in a 12-year-old girl |
title_fullStr | Marked improvement in febrile infection-related epilepsy syndrome after lidocaine plus MgSO(4) treatment in a 12-year-old girl |
title_full_unstemmed | Marked improvement in febrile infection-related epilepsy syndrome after lidocaine plus MgSO(4) treatment in a 12-year-old girl |
title_short | Marked improvement in febrile infection-related epilepsy syndrome after lidocaine plus MgSO(4) treatment in a 12-year-old girl |
title_sort | marked improvement in febrile infection-related epilepsy syndrome after lidocaine plus mgso(4) treatment in a 12-year-old girl |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917485/ https://www.ncbi.nlm.nih.gov/pubmed/27358770 http://dx.doi.org/10.1016/j.ebcr.2016.05.002 |
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