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Emerging ST121/agr4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly
The pathogenesis of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) pneumonia in influenza-infected elderly individuals has not yet been elucidated in detail. In the present study, a 92-year-old man infected with influenza developed CA-MRSA pneumonia. His CA-MRSA was an em...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917487/ https://www.ncbi.nlm.nih.gov/pubmed/27358743 http://dx.doi.org/10.1016/j.nmni.2016.05.011 |
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author | Wan, T.-W. Tomita, Y. Saita, N. Konno, K. Iwao, Y. Hung, W.-C. Teng, L.-J. Yamamoto, T. |
author_facet | Wan, T.-W. Tomita, Y. Saita, N. Konno, K. Iwao, Y. Hung, W.-C. Teng, L.-J. Yamamoto, T. |
author_sort | Wan, T.-W. |
collection | PubMed |
description | The pathogenesis of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) pneumonia in influenza-infected elderly individuals has not yet been elucidated in detail. In the present study, a 92-year-old man infected with influenza developed CA-MRSA pneumonia. His CA-MRSA was an emerging type, originated in ST121/agr4 S. aureus, with diversities of Panton–Valentine leucocidin (PVL)(−)/spat5110/SCCmecV(+) versus PVL(+)/spat159((etc.))/SCCmec(−), but with common virulence potentials of strong adhesin and cytolytic activities. Resistance to erythromycin/clindamycin (inducible-type) and gentamicin was detected. Pneumonia improved with the administration of levofloxacin, but with the subsequent development of fatal aspiration pneumonia. Hence, characteristic CA-MRSA with strong adhesin and cytolytic activities triggered influenza-related sequential complications. |
format | Online Article Text |
id | pubmed-4917487 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-49174872016-06-29 Emerging ST121/agr4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly Wan, T.-W. Tomita, Y. Saita, N. Konno, K. Iwao, Y. Hung, W.-C. Teng, L.-J. Yamamoto, T. New Microbes New Infect New Resistant Microbes in Humans The pathogenesis of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) pneumonia in influenza-infected elderly individuals has not yet been elucidated in detail. In the present study, a 92-year-old man infected with influenza developed CA-MRSA pneumonia. His CA-MRSA was an emerging type, originated in ST121/agr4 S. aureus, with diversities of Panton–Valentine leucocidin (PVL)(−)/spat5110/SCCmecV(+) versus PVL(+)/spat159((etc.))/SCCmec(−), but with common virulence potentials of strong adhesin and cytolytic activities. Resistance to erythromycin/clindamycin (inducible-type) and gentamicin was detected. Pneumonia improved with the administration of levofloxacin, but with the subsequent development of fatal aspiration pneumonia. Hence, characteristic CA-MRSA with strong adhesin and cytolytic activities triggered influenza-related sequential complications. Elsevier 2016-05-26 /pmc/articles/PMC4917487/ /pubmed/27358743 http://dx.doi.org/10.1016/j.nmni.2016.05.011 Text en © 2016 Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | New Resistant Microbes in Humans Wan, T.-W. Tomita, Y. Saita, N. Konno, K. Iwao, Y. Hung, W.-C. Teng, L.-J. Yamamoto, T. Emerging ST121/agr4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly |
title | Emerging ST121/agr4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly |
title_full | Emerging ST121/agr4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly |
title_fullStr | Emerging ST121/agr4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly |
title_full_unstemmed | Emerging ST121/agr4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly |
title_short | Emerging ST121/agr4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly |
title_sort | emerging st121/agr4 community-associated methicillin-resistant staphylococcus aureus (mrsa) with strong adhesin and cytolytic activities: trigger for mrsa pneumonia and fatal aspiration pneumonia in an influenza-infected elderly |
topic | New Resistant Microbes in Humans |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917487/ https://www.ncbi.nlm.nih.gov/pubmed/27358743 http://dx.doi.org/10.1016/j.nmni.2016.05.011 |
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