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Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis
Mitochondrial impairment induced by oxidative stress is a main characteristic of intrinsic cell death pathways in neurons underlying the pathology of neurodegenerative diseases. Therefore, protection of mitochondrial integrity and function is emerging as a promising strategy to prevent neuronal dama...
Autores principales: | Neitemeier, S, Dolga, A M, Honrath, B, Karuppagounder, S S, Alim, I, Ratan, R R, Culmsee, C |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917646/ https://www.ncbi.nlm.nih.gov/pubmed/27148687 http://dx.doi.org/10.1038/cddis.2016.107 |
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