SP6616 as a new Kv2.1 channel inhibitor efficiently promotes β-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways

Kv2.1 as a voltage-gated potassium (Kv) channel subunit has a pivotal role in the regulation of glucose-stimulated insulin secretion (GSIS) and pancreatic β-cell apoptosis, and is believed to be a promising target for anti-diabetic drug discovery, although the mechanism underlying the Kv2.1-mediated...

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Detalles Bibliográficos
Autores principales: Zhou, T T, Quan, L L, Chen, L P, Du, T, Sun, K X, Zhang, J C, Yu, L, Li, Y, Wan, P, Chen, L L, Jiang, B H, Hu, L H, Chen, J, Shen, X
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917657/
https://www.ncbi.nlm.nih.gov/pubmed/27148689
http://dx.doi.org/10.1038/cddis.2016.119

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