Cargando…

Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer

Tumor cells exhibit unique metabolic adaptations that are increasingly viewed as potential targets for novel and specific cancer therapies. Among these targets, the carnitine palmitoyltransferase system is responsible for delivering the long-chain fatty acid (FA) from cytoplasm into mitochondria for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qu, Q, Zeng, F, Liu, X, Wang, Q J, Deng, F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917665/ https://www.ncbi.nlm.nih.gov/pubmed/27195673 http://dx.doi.org/10.1038/cddis.2016.132

Ejemplares similares

Carnitine palmitoyltransferase 2 deficiency, malignant hyperthermia and anesthesia
por: Glauber, Violeta, et al.
Publicado: (2014)

Severe rhabdomyolysis in homozygote carnitine palmitoyltransferase II deficiency
por: Schnedl, Wolfgang J., et al.
Publicado: (2020)

Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation
por: Yao, Cong-Hui, et al.
Publicado: (2018)

Carnitine Palmitoyltransferase System: A New Target for Anti-Inflammatory and Anticancer Therapy?
por: Wang, Muyun, et al.
Publicado: (2021)

Mitochondrial carnitine palmitoyltransferase-II dysfunction: A possible novel mechanism for nonalcoholic fatty liver disease in hepatocarcinogenesis
por: Yao, Min, et al.
Publicado: (2023)

Stabilization of the thermolabile variant S113L of carnitine palmitoyltransferase II
por: Motlagh, Leila, et al.
Publicado: (2016)

Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence
por: Wang, Yongtao, et al.
Publicado: (2020)

Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet–Induced Insulin Resistance
por: Bruce, Clinton R., et al.
Publicado: (2009)

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity
por: Kurmi, Kiran, et al.
Publicado: (2018)

Carnitine Palmitoyltransferase 1 Regulates Prostate Cancer Growth under Hypoxia
por: Rios-Colon, Leslimar, et al.
Publicado: (2021)

PSUN63 Approach to hyperlipidemia management in Carnitine Palmitoyltransferase II deficiency
por: Anbari, Raghda A, et al.
Publicado: (2022)

Carnitine Palmitoyltransferase 1b Deficiency Protects Mice from Diet-Induced Insulin Resistance
por: Kim, Teayoun, et al.
Publicado: (2014)

Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4(+) T cell apoptosis promoting HCC development
por: Brown, Zachary J., et al.
Publicado: (2018)

Muscle Carnitine Palmitoyltransferase II (CPT II) Deficiency: A Conceptual Approach
por: Joshi, Pushpa Raj, et al.
Publicado: (2020)

A Case of Carnitine Palmitoyltransferase II Deficiency in Bahrain With a Novel Mutation
por: Alsahlawi, Zahra, et al.
Publicado: (2022)

From recurrent rhabdomyolysis in a young adult to carnitine palmitoyltransferase II deficiency
por: Marques, Cristina, et al.
Publicado: (2023)

Apigenin Attenuates Acetaminophen-Induced Hepatotoxicity by Activating AMP-Activated Protein Kinase/Carnitine Palmitoyltransferase I Pathway
por: Zhang, Jiaqi, et al.
Publicado: (2020)

Abbreviated Half-Lives and Impaired Fuel Utilization in Carnitine Palmitoyltransferase II Variant Fibroblasts
por: Yao, Min, et al.
Publicado: (2015)

Muscle Carnitine Palmitoyltransferase II Deficiency: A Review of Enzymatic Controversy and Clinical Features
por: Lehmann, Diana, et al.
Publicado: (2017)

Carnitine Palmitoyltransferase II Deficiency (CPT II) Followed By Rhabdomyolysis and Acute Kidney Injury
por: Gjorgjievski, Nikola, et al.
Publicado: (2018)

Hepatic β-Oxidation and Regulation of Carnitine Palmitoyltransferase (CPT) I in Blunt Snout Bream Megalobrama amblycephala Fed a High Fat Diet
por: Lu, Kang-Le, et al.
Publicado: (2014)

Une cardiomyopathie révélant un déficit en carnitine palmitoyltransférase I: à propos d’un cas inhabituel
por: Fetoui, Imane, et al.
Publicado: (2020)

Knockdown of carnitine palmitoyltransferase I (CPT1) reduces fat body lipid mobilization and resistance to starvation in the insect vector Rhodnius prolixus
por: De Paula, Iron F., et al.
Publicado: (2023)

Carnitine Palmitoyltransferase 1 Increases Lipolysis, UCP1 Protein Expression and Mitochondrial Activity in Brown Adipocytes
por: Calderon-Dominguez, María, et al.
Publicado: (2016)

Evidence for an Association Between Infant Mortality and Homozygosity For the Arctic Variant of Carnitine Palmitoyltransferase 1A
por: Gessner, Bradford D., et al.
Publicado: (2016)

Inhibition of Carnitine Palmitoyltransferase-1 Activity Alleviates Insulin Resistance in Diet-Induced Obese Mice
por: Keung, Wendy, et al.
Publicado: (2013)

Isothermal titration calorimetry with micelles: Thermodynamics of inhibitor binding to carnitine palmitoyltransferase 2 membrane protein()
por: Perspicace, Samantha, et al.
Publicado: (2013)

Recurrent rhabdomyolysis caused by carnitine palmitoyltransferase II deficiency, common but under-recognised: Lessons to be learnt
por: Balasubramanian, M., et al.
Publicado: (2018)

Endogenous genetic risk factor for serious heatstroke: the thermolabile phenotype of carnitine palmitoyltransferase II variant
por: Oda, Jun, et al.
Publicado: (2018)

Normal FGF-21-Serum Levels in Patients with Carnitine Palmitoyltransferase II (CPT II) Deficiency
por: Motlagh Scholle, Leila, et al.
Publicado: (2019)

A surviving 24-month-old patient with neonatal-onset carnitine palmitoyltransferase II deficiency
por: Ikeda, Naohiro, et al.
Publicado: (2017)

Identification and Characterization of Carnitine Palmitoyltransferase 1 (cpt 1) Genes in Nile Tilapia, Oreochromis niloticus
por: Bayır, Mehtap, et al.
Publicado: (2020)

Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence
por: Zhang, Huizhen, et al.
Publicado: (2021)

Carnitine palmitoyltransferase 1A promotes mitochondrial fission by enhancing MFF succinylation in ovarian cancer
por: Zhu, Yaqin, et al.
Publicado: (2023)

Inhibition of androgen receptor can decrease fat metabolism by decreasing carnitine palmitoyltransferase I levels in skeletal muscles of trained mice
por: Kim, Jisu, et al.
Publicado: (2019)

Loss of carnitine palmitoyltransferase 1a reduces docosahexaenoic acid-containing phospholipids and drives sexually dimorphic liver disease in mice
por: Zelows, Mikala M., et al.
Publicado: (2023)

Upregulating carnitine palmitoyltransferase 1 attenuates hyperoxia-induced endothelial cell dysfunction and persistent lung injury
por: Chang, Jason L., et al.
Publicado: (2022)

The impact of variance in carnitine palmitoyltransferase-1 expression on breast cancer prognosis is stratified by clinical and anthropometric factors
por: Liu, Ryan, et al.
Publicado: (2023)

The Reversible Carnitine Palmitoyltransferase 1 Inhibitor (Teglicar) Ameliorates the Neurodegenerative Phenotype in a Drosophila Huntington’s Disease Model by Acting on the Expression of Carnitine-Related Genes
por: Bertapelle, Carla, et al.
Publicado: (2022)

Detection of Early Onset Carnitine Palmitoyltransferase II Deficiency by Newborn Screening: Should CPT II Deficiency Be a Primary Disease Target?
por: Mador-House, Rachel, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rena7e1vpsm8v3g84fhkvfd8l4