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Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma
A reversibility test by an increase of greater than 12% in FEV1 can support a diagnosis of asthma and alter a patient's treatment plan but may not be applicable to the young ages. We retrospectively gathered spirometric data from 85/271 asthmatic children having mild obstruction (FEV1 > 80%...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917687/ https://www.ncbi.nlm.nih.gov/pubmed/27445548 http://dx.doi.org/10.1155/2016/5394876 |
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author | Vilozni, Daphna Hakim, Fahed Livnat, Galit Ofek, Miryam Bar-Yoseph, Ronen Bentur, Lea |
author_facet | Vilozni, Daphna Hakim, Fahed Livnat, Galit Ofek, Miryam Bar-Yoseph, Ronen Bentur, Lea |
author_sort | Vilozni, Daphna |
collection | PubMed |
description | A reversibility test by an increase of greater than 12% in FEV1 can support a diagnosis of asthma and alter a patient's treatment plan but may not be applicable to the young ages. We retrospectively gathered spirometric data from 85/271 asthmatic children having mild obstruction (FEV1 > 80% predicted), age 2.6–6.9 years. Spirometry was performed before and 20 min after inhalation of 200 mcg Albuterol. We defined a deviation below −1.64 z scores from control as obstruction and an increased above 1.64 scores from control as a positive response to bronchodilators. Sensitivity of the index was considered significant if it captured >68% of the participants. The sensitivity of detecting airway obstruction in these children by FEV1 was 15.3% and 62.4% by FEF25–75. A positive response to Albuterol was an increase of 9.2% for FEV1 (12% for adults) and 18.5% for FEF25–75. The sensitivity for detecting a response to Albuterol in mild asthma was 64.7% by FEV1 and 91.8% by FEF25–75. Young children having normal spirometry can demonstrate airway reversibility. The response of spirometry parameters to bronchodilators may be more sensitive than obstruction detection and may help to support the diagnosis of asthma and adjust treatment plan. |
format | Online Article Text |
id | pubmed-4917687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49176872016-07-04 Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma Vilozni, Daphna Hakim, Fahed Livnat, Galit Ofek, Miryam Bar-Yoseph, Ronen Bentur, Lea Can Respir J Research Article A reversibility test by an increase of greater than 12% in FEV1 can support a diagnosis of asthma and alter a patient's treatment plan but may not be applicable to the young ages. We retrospectively gathered spirometric data from 85/271 asthmatic children having mild obstruction (FEV1 > 80% predicted), age 2.6–6.9 years. Spirometry was performed before and 20 min after inhalation of 200 mcg Albuterol. We defined a deviation below −1.64 z scores from control as obstruction and an increased above 1.64 scores from control as a positive response to bronchodilators. Sensitivity of the index was considered significant if it captured >68% of the participants. The sensitivity of detecting airway obstruction in these children by FEV1 was 15.3% and 62.4% by FEF25–75. A positive response to Albuterol was an increase of 9.2% for FEV1 (12% for adults) and 18.5% for FEF25–75. The sensitivity for detecting a response to Albuterol in mild asthma was 64.7% by FEV1 and 91.8% by FEF25–75. Young children having normal spirometry can demonstrate airway reversibility. The response of spirometry parameters to bronchodilators may be more sensitive than obstruction detection and may help to support the diagnosis of asthma and adjust treatment plan. Hindawi Publishing Corporation 2016 2016-06-09 /pmc/articles/PMC4917687/ /pubmed/27445548 http://dx.doi.org/10.1155/2016/5394876 Text en Copyright © 2016 Daphna Vilozni et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Vilozni, Daphna Hakim, Fahed Livnat, Galit Ofek, Miryam Bar-Yoseph, Ronen Bentur, Lea Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma |
title | Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma |
title_full | Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma |
title_fullStr | Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma |
title_full_unstemmed | Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma |
title_short | Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma |
title_sort | assessment of airway bronchodilation by spirometry compared to airway obstruction in young children with asthma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917687/ https://www.ncbi.nlm.nih.gov/pubmed/27445548 http://dx.doi.org/10.1155/2016/5394876 |
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