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Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma

A reversibility test by an increase of greater than 12% in FEV1 can support a diagnosis of asthma and alter a patient's treatment plan but may not be applicable to the young ages. We retrospectively gathered spirometric data from 85/271 asthmatic children having mild obstruction (FEV1 > 80%...

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Autores principales: Vilozni, Daphna, Hakim, Fahed, Livnat, Galit, Ofek, Miryam, Bar-Yoseph, Ronen, Bentur, Lea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917687/
https://www.ncbi.nlm.nih.gov/pubmed/27445548
http://dx.doi.org/10.1155/2016/5394876
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author Vilozni, Daphna
Hakim, Fahed
Livnat, Galit
Ofek, Miryam
Bar-Yoseph, Ronen
Bentur, Lea
author_facet Vilozni, Daphna
Hakim, Fahed
Livnat, Galit
Ofek, Miryam
Bar-Yoseph, Ronen
Bentur, Lea
author_sort Vilozni, Daphna
collection PubMed
description A reversibility test by an increase of greater than 12% in FEV1 can support a diagnosis of asthma and alter a patient's treatment plan but may not be applicable to the young ages. We retrospectively gathered spirometric data from 85/271 asthmatic children having mild obstruction (FEV1 > 80% predicted), age 2.6–6.9 years. Spirometry was performed before and 20 min after inhalation of 200 mcg Albuterol. We defined a deviation below −1.64 z scores from control as obstruction and an increased above 1.64 scores from control as a positive response to bronchodilators. Sensitivity of the index was considered significant if it captured >68% of the participants. The sensitivity of detecting airway obstruction in these children by FEV1 was 15.3% and 62.4% by FEF25–75. A positive response to Albuterol was an increase of 9.2% for FEV1 (12% for adults) and 18.5% for FEF25–75. The sensitivity for detecting a response to Albuterol in mild asthma was 64.7% by FEV1 and 91.8% by FEF25–75. Young children having normal spirometry can demonstrate airway reversibility. The response of spirometry parameters to bronchodilators may be more sensitive than obstruction detection and may help to support the diagnosis of asthma and adjust treatment plan.
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spelling pubmed-49176872016-07-04 Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma Vilozni, Daphna Hakim, Fahed Livnat, Galit Ofek, Miryam Bar-Yoseph, Ronen Bentur, Lea Can Respir J Research Article A reversibility test by an increase of greater than 12% in FEV1 can support a diagnosis of asthma and alter a patient's treatment plan but may not be applicable to the young ages. We retrospectively gathered spirometric data from 85/271 asthmatic children having mild obstruction (FEV1 > 80% predicted), age 2.6–6.9 years. Spirometry was performed before and 20 min after inhalation of 200 mcg Albuterol. We defined a deviation below −1.64 z scores from control as obstruction and an increased above 1.64 scores from control as a positive response to bronchodilators. Sensitivity of the index was considered significant if it captured >68% of the participants. The sensitivity of detecting airway obstruction in these children by FEV1 was 15.3% and 62.4% by FEF25–75. A positive response to Albuterol was an increase of 9.2% for FEV1 (12% for adults) and 18.5% for FEF25–75. The sensitivity for detecting a response to Albuterol in mild asthma was 64.7% by FEV1 and 91.8% by FEF25–75. Young children having normal spirometry can demonstrate airway reversibility. The response of spirometry parameters to bronchodilators may be more sensitive than obstruction detection and may help to support the diagnosis of asthma and adjust treatment plan. Hindawi Publishing Corporation 2016 2016-06-09 /pmc/articles/PMC4917687/ /pubmed/27445548 http://dx.doi.org/10.1155/2016/5394876 Text en Copyright © 2016 Daphna Vilozni et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Vilozni, Daphna
Hakim, Fahed
Livnat, Galit
Ofek, Miryam
Bar-Yoseph, Ronen
Bentur, Lea
Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma
title Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma
title_full Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma
title_fullStr Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma
title_full_unstemmed Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma
title_short Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma
title_sort assessment of airway bronchodilation by spirometry compared to airway obstruction in young children with asthma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917687/
https://www.ncbi.nlm.nih.gov/pubmed/27445548
http://dx.doi.org/10.1155/2016/5394876
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