Safety, pharmacokinetics and pharmacodynamics of GLPG0974, a potent and selective FFA2 antagonist, in healthy male subjects

AIMS: Free fatty acids (FFA) can act as direct signalling molecules through activation of several membrane‐bound G‐protein coupled receptors. The FFA2 receptor (known as GPR43) is activated by short chain fatty acids (SCFA) such as acetate and has been shown to play a major role in SCFA‐induced neut...

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Detalles Bibliográficos
Autores principales: Namour, Florence, Galien, René, Van Kaem, Tim, Van der Aa, Annegret, Vanhoutte, Frédéric, Beetens, Johan, van't Klooster, Gerben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Pharmacokinetic Dynamic Relationships
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917808/
https://www.ncbi.nlm.nih.gov/pubmed/26852904
http://dx.doi.org/10.1111/bcp.12900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917808/
https://www.ncbi.nlm.nih.gov/pubmed/26852904
http://dx.doi.org/10.1111/bcp.12900

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