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The role of inflammatory cytokines and ERK1/2 signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders

Mental health disorders(MHD) in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) have been widely studied. However, the underlying role of inflammatory cytokines and their associated signaling pathways have not been investigated. Here, we report the potential role of cytokines and associat...

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Autores principales: Hu, Chao, Yang, Hualan, Zhao, Yanfang, Chen, Xiang, Dong, Yinying, Li, Long, Dong, Yehao, Cui, Jiefeng, Zhu, Tongyu, Zheng, Ping, Lin, Ching-Shwun, Dai, Jican
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917855/
https://www.ncbi.nlm.nih.gov/pubmed/27334333
http://dx.doi.org/10.1038/srep28608
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author Hu, Chao
Yang, Hualan
Zhao, Yanfang
Chen, Xiang
Dong, Yinying
Li, Long
Dong, Yehao
Cui, Jiefeng
Zhu, Tongyu
Zheng, Ping
Lin, Ching-Shwun
Dai, Jican
author_facet Hu, Chao
Yang, Hualan
Zhao, Yanfang
Chen, Xiang
Dong, Yinying
Li, Long
Dong, Yehao
Cui, Jiefeng
Zhu, Tongyu
Zheng, Ping
Lin, Ching-Shwun
Dai, Jican
author_sort Hu, Chao
collection PubMed
description Mental health disorders(MHD) in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) have been widely studied. However, the underlying role of inflammatory cytokines and their associated signaling pathways have not been investigated. Here, we report the potential role of cytokines and associated signaling pathways in CP/CPPS patients with MHD and in a CP/CPPS animal model. CP/CPPS patients (n = 810) and control subjects (n = 992) were enrolled in this case-control multicenter study, and serum cytokine levels were measured. Male Sprague-Dawley rats received multiple intracutaneous injections of an immuno-agent along with a pertussis-diphtheria-tetanus triple vaccine for autoimmune CP/CPPS development. The results revealed that, in CP/CPPS patients with significant MHD, elevated IL-1α, IL-1β, IL-4, IL-13, and TNF-α serum levels were observed. The above five cytokines in CP/CPPS rats were significantly elevated in prostate tissue (p < 0.05), and IL-1β levels were elevated in serum and cerebrospinal fluid. In behavioral tests, CP/CPPS rats showed anxiety- and depression-like symptoms, and impaired spatial and associative memory performance (p < 0.05). In the CP/CPPS group, ERK1/2 phosphorylation levels were increased in the amygdala and nucleus accumbens, and decreased in the hippocampus, but not caudate nucleus. Thus, prostate-derived cytokines, especially IL-1β, cross the blood brain barrier and may lead to enhanced ERK1/2 signaling in several brain areas, possibly underlying induction of CP/CPPS-related MHD.
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spelling pubmed-49178552016-06-27 The role of inflammatory cytokines and ERK1/2 signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders Hu, Chao Yang, Hualan Zhao, Yanfang Chen, Xiang Dong, Yinying Li, Long Dong, Yehao Cui, Jiefeng Zhu, Tongyu Zheng, Ping Lin, Ching-Shwun Dai, Jican Sci Rep Article Mental health disorders(MHD) in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) have been widely studied. However, the underlying role of inflammatory cytokines and their associated signaling pathways have not been investigated. Here, we report the potential role of cytokines and associated signaling pathways in CP/CPPS patients with MHD and in a CP/CPPS animal model. CP/CPPS patients (n = 810) and control subjects (n = 992) were enrolled in this case-control multicenter study, and serum cytokine levels were measured. Male Sprague-Dawley rats received multiple intracutaneous injections of an immuno-agent along with a pertussis-diphtheria-tetanus triple vaccine for autoimmune CP/CPPS development. The results revealed that, in CP/CPPS patients with significant MHD, elevated IL-1α, IL-1β, IL-4, IL-13, and TNF-α serum levels were observed. The above five cytokines in CP/CPPS rats were significantly elevated in prostate tissue (p < 0.05), and IL-1β levels were elevated in serum and cerebrospinal fluid. In behavioral tests, CP/CPPS rats showed anxiety- and depression-like symptoms, and impaired spatial and associative memory performance (p < 0.05). In the CP/CPPS group, ERK1/2 phosphorylation levels were increased in the amygdala and nucleus accumbens, and decreased in the hippocampus, but not caudate nucleus. Thus, prostate-derived cytokines, especially IL-1β, cross the blood brain barrier and may lead to enhanced ERK1/2 signaling in several brain areas, possibly underlying induction of CP/CPPS-related MHD. Nature Publishing Group 2016-06-23 /pmc/articles/PMC4917855/ /pubmed/27334333 http://dx.doi.org/10.1038/srep28608 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Hu, Chao
Yang, Hualan
Zhao, Yanfang
Chen, Xiang
Dong, Yinying
Li, Long
Dong, Yehao
Cui, Jiefeng
Zhu, Tongyu
Zheng, Ping
Lin, Ching-Shwun
Dai, Jican
The role of inflammatory cytokines and ERK1/2 signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders
title The role of inflammatory cytokines and ERK1/2 signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders
title_full The role of inflammatory cytokines and ERK1/2 signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders
title_fullStr The role of inflammatory cytokines and ERK1/2 signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders
title_full_unstemmed The role of inflammatory cytokines and ERK1/2 signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders
title_short The role of inflammatory cytokines and ERK1/2 signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders
title_sort role of inflammatory cytokines and erk1/2 signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917855/
https://www.ncbi.nlm.nih.gov/pubmed/27334333
http://dx.doi.org/10.1038/srep28608
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