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Induction of action-at-a-distance mutagenesis by 8-oxo-7,8-dihydroguanine in DNA pol λ-knockdown cells

INTRODUCTION: In DNA, 8-oxo-7,8-dihydroguanine (G(O), 8-hydroxyguanine) is one of the most pivotal oxidatively damaged bases and induces G:C → T:A transversion mutations. DNA polymerase λ preferentially inserts dCTP opposite G(O)in vitro, and this error-free bypass function is considered to be impor...

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Detalles Bibliográficos
Autores principales:	Kamiya, Hiroyuki, Kurokawa, Masahiro, Makino, Tetsuaki, Kobayashi, Miwako, Matsuoka, Ichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918004/ https://www.ncbi.nlm.nih.gov/pubmed/27350807 http://dx.doi.org/10.1186/s41021-015-0015-7

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