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Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation

INTRODUCTION: Hepatic cytochrome P450s (CYPs) play an important role in the metabolism of plant carcinogen, aristolochic acid I (AAI). In the present study, we employed hepatic NADPH-cytochrome P450 reductase null (HRN) gpt delta transgenic mice to investigate the role of hepatic CYPs in the metabol...

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Detalles Bibliográficos
Autores principales:	Luan, Yang, Xing, Guozhen, Ren, Jin, Gu, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918019/ https://www.ncbi.nlm.nih.gov/pubmed/27350808 http://dx.doi.org/10.1186/s41021-015-0010-z

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