Cargando…
Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives
The modern medical literature implicates malaria, and particularly the potentially fatal form of cerebral malaria, with a risk of neurocognitive impairment. Yet historically, even milder forms of malaria were associated in the literature with a broad range of psychiatric effects, including disorders...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918116/ https://www.ncbi.nlm.nih.gov/pubmed/27335053 http://dx.doi.org/10.1186/s12936-016-1391-6 |
_version_ | 1782439059768999936 |
---|---|
author | Nevin, Remington L. Croft, Ashley M. |
author_facet | Nevin, Remington L. Croft, Ashley M. |
author_sort | Nevin, Remington L. |
collection | PubMed |
description | The modern medical literature implicates malaria, and particularly the potentially fatal form of cerebral malaria, with a risk of neurocognitive impairment. Yet historically, even milder forms of malaria were associated in the literature with a broad range of psychiatric effects, including disorders of personality, mood, memory, attention, thought, and behaviour. In this article, the history of psychiatric effects attributed to malaria and post-malaria syndromes is reviewed, and insights from the historical practice of malariotherapy in contributing to understanding of these effects are considered. This review concludes with a discussion of the potentially confounding role of the adverse effects of anti-malarial drugs, particularly of the quinoline class, in the unique attribution of certain psychiatric effects to malaria, and of the need for a critical reevaluation of the literature in light of emerging evidence of the chronic nature of these adverse drug effects. |
format | Online Article Text |
id | pubmed-4918116 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-49181162016-06-24 Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives Nevin, Remington L. Croft, Ashley M. Malar J Review The modern medical literature implicates malaria, and particularly the potentially fatal form of cerebral malaria, with a risk of neurocognitive impairment. Yet historically, even milder forms of malaria were associated in the literature with a broad range of psychiatric effects, including disorders of personality, mood, memory, attention, thought, and behaviour. In this article, the history of psychiatric effects attributed to malaria and post-malaria syndromes is reviewed, and insights from the historical practice of malariotherapy in contributing to understanding of these effects are considered. This review concludes with a discussion of the potentially confounding role of the adverse effects of anti-malarial drugs, particularly of the quinoline class, in the unique attribution of certain psychiatric effects to malaria, and of the need for a critical reevaluation of the literature in light of emerging evidence of the chronic nature of these adverse drug effects. BioMed Central 2016-06-22 /pmc/articles/PMC4918116/ /pubmed/27335053 http://dx.doi.org/10.1186/s12936-016-1391-6 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Nevin, Remington L. Croft, Ashley M. Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives |
title | Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives |
title_full | Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives |
title_fullStr | Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives |
title_full_unstemmed | Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives |
title_short | Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives |
title_sort | psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918116/ https://www.ncbi.nlm.nih.gov/pubmed/27335053 http://dx.doi.org/10.1186/s12936-016-1391-6 |
work_keys_str_mv | AT nevinremingtonl psychiatriceffectsofmalariaandantimalarialdrugshistoricalandmodernperspectives AT croftashleym psychiatriceffectsofmalariaandantimalarialdrugshistoricalandmodernperspectives |