Tropheryma whipplei as a Cause of Epidemic Fever, Senegal, 2010–2012

The bacterium Tropheryma whipplei, which causes Whipple disease in humans, is commonly detected in the feces of persons in Africa. It is also associated with acute infections. We investigated the role of T. whipplei in febrile patients from 2 rural villages in Senegal. During June 2010–March 2012, w...

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Autores principales: Bassene, Hubert, Mediannikov, Oleg, Socolovschi, Cristina, Ratmanov, Pavel, Keita, Alpha K., Sokhna, Cheikh, Raoult, Didier, Fenollar, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918168/
https://www.ncbi.nlm.nih.gov/pubmed/27314980
http://dx.doi.org/10.3201/eid2207.150441
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author Bassene, Hubert
Mediannikov, Oleg
Socolovschi, Cristina
Ratmanov, Pavel
Keita, Alpha K.
Sokhna, Cheikh
Raoult, Didier
Fenollar, Florence
author_facet Bassene, Hubert
Mediannikov, Oleg
Socolovschi, Cristina
Ratmanov, Pavel
Keita, Alpha K.
Sokhna, Cheikh
Raoult, Didier
Fenollar, Florence
author_sort Bassene, Hubert
collection PubMed
description The bacterium Tropheryma whipplei, which causes Whipple disease in humans, is commonly detected in the feces of persons in Africa. It is also associated with acute infections. We investigated the role of T. whipplei in febrile patients from 2 rural villages in Senegal. During June 2010–March 2012, we collected whole-blood finger-prick samples from 786 febrile and 385 healthy villagers. T. whipplei was detected in blood specimens from 36 (4.6%) of the 786 febrile patients and in 1 (0.25%) of the 385 apparently healthy persons. Of the 37 T. whipplei cases, 26 (70.2%) were detected in August 2010. Familial cases and a potential new genotype were observed. The patients’ symptoms were mainly headache (68.9%) and cough (36.1%). Our findings suggest that T. whipplei is a cause of epidemic fever in Senegal.
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spelling pubmed-49181682016-07-01 Tropheryma whipplei as a Cause of Epidemic Fever, Senegal, 2010–2012 Bassene, Hubert Mediannikov, Oleg Socolovschi, Cristina Ratmanov, Pavel Keita, Alpha K. Sokhna, Cheikh Raoult, Didier Fenollar, Florence Emerg Infect Dis Research The bacterium Tropheryma whipplei, which causes Whipple disease in humans, is commonly detected in the feces of persons in Africa. It is also associated with acute infections. We investigated the role of T. whipplei in febrile patients from 2 rural villages in Senegal. During June 2010–March 2012, we collected whole-blood finger-prick samples from 786 febrile and 385 healthy villagers. T. whipplei was detected in blood specimens from 36 (4.6%) of the 786 febrile patients and in 1 (0.25%) of the 385 apparently healthy persons. Of the 37 T. whipplei cases, 26 (70.2%) were detected in August 2010. Familial cases and a potential new genotype were observed. The patients’ symptoms were mainly headache (68.9%) and cough (36.1%). Our findings suggest that T. whipplei is a cause of epidemic fever in Senegal. Centers for Disease Control and Prevention 2016-07 /pmc/articles/PMC4918168/ /pubmed/27314980 http://dx.doi.org/10.3201/eid2207.150441 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Bassene, Hubert
Mediannikov, Oleg
Socolovschi, Cristina
Ratmanov, Pavel
Keita, Alpha K.
Sokhna, Cheikh
Raoult, Didier
Fenollar, Florence
Tropheryma whipplei as a Cause of Epidemic Fever, Senegal, 2010–2012
title Tropheryma whipplei as a Cause of Epidemic Fever, Senegal, 2010–2012
title_full Tropheryma whipplei as a Cause of Epidemic Fever, Senegal, 2010–2012
title_fullStr Tropheryma whipplei as a Cause of Epidemic Fever, Senegal, 2010–2012
title_full_unstemmed Tropheryma whipplei as a Cause of Epidemic Fever, Senegal, 2010–2012
title_short Tropheryma whipplei as a Cause of Epidemic Fever, Senegal, 2010–2012
title_sort tropheryma whipplei as a cause of epidemic fever, senegal, 2010–2012
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918168/
https://www.ncbi.nlm.nih.gov/pubmed/27314980
http://dx.doi.org/10.3201/eid2207.150441
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