Cargando…
Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study
BACKGROUND: Paraoxonase 1 (PON1) gene polymorphisms and polyphenols intake have been reported independently associated to lipid profile and susceptibility to atherosclerosis and cardiovascular disease. However, the interaction between these factors remains to be investigated. We performed an observa...
Autores principales: | , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918189/ https://www.ncbi.nlm.nih.gov/pubmed/27338244 http://dx.doi.org/10.1186/s12967-016-0941-6 |
_version_ | 1782439076513710080 |
---|---|
author | Rizzi, Federica Conti, Costanza Dogliotti, Elena Terranegra, Annalisa Salvi, Erika Braga, Daniele Ricca, Flavia Lupoli, Sara Mingione, Alessandra Pivari, Francesca Brasacchio, Caterina Barcella, Matteo Chittani, Martina D’Avila, Francesca Turiel, Maurizio Lazzaroni, Monica Soldati, Laura Cusi, Daniele Barlassina, Cristina |
author_facet | Rizzi, Federica Conti, Costanza Dogliotti, Elena Terranegra, Annalisa Salvi, Erika Braga, Daniele Ricca, Flavia Lupoli, Sara Mingione, Alessandra Pivari, Francesca Brasacchio, Caterina Barcella, Matteo Chittani, Martina D’Avila, Francesca Turiel, Maurizio Lazzaroni, Monica Soldati, Laura Cusi, Daniele Barlassina, Cristina |
author_sort | Rizzi, Federica |
collection | PubMed |
description | BACKGROUND: Paraoxonase 1 (PON1) gene polymorphisms and polyphenols intake have been reported independently associated to lipid profile and susceptibility to atherosclerosis and cardiovascular disease. However, the interaction between these factors remains to be investigated. We performed an observational nutrigenetic study to examine whether the interaction between polyphenols and anthocyanins intake and PON1 genetic variants can modulate biomarkers of cardiovascular health in an Italian healthy population. METHODS: We recruited 443 healthy volunteers who participated in the EC funded ATHENA project (AnThocyanin and polyphenols bioactive for Health Enhancement through Nutritional Advancement). Data collection included detailed demographic, clinical, dietary, lifestyle, biochemical and genetic data. Polyphenols and anthocyanins intake was measured by 24 h dietary recall repeated three times a year in order to get seasonal variations. We tested the interaction between 18 independent tagging SNPs in PON1 gene and polyphenols intake on HDL, LDL, cholesterol, triglycerides and atherogenic index of plasma. RESULTS: Without considering the genetic background, we could not observe significant differences in the lipid profile between high and low polyphenols and anthocyanins intake. Using a nutrigenetic approach, we identified protective genotypes in four independent polymorphisms that, at Bonferroni level (p ≤ 0.0028), present a significant association with increased HDL level under high polyphenols and anthocyanins intake, compared to risk genotypes (rs854549, Beta = 4.7 per C allele; rs854552, Beta = 5.6 per C allele; rs854571, Beta = 3.92 per T allele; rs854572, Beta = 3.94 per C allele). CONCLUSIONS: We highlight the protective role of genetic variants in PON1 towards cardiovascular risk under high polyphenols and anthocyanins consumption. PON1 variants could represent novel biomarkers to stratify individuals who might benefit from targeted dietary recommendation for health promotion and strategies of preventive medicine. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12967-016-0941-6) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4918189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-49181892016-06-24 Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study Rizzi, Federica Conti, Costanza Dogliotti, Elena Terranegra, Annalisa Salvi, Erika Braga, Daniele Ricca, Flavia Lupoli, Sara Mingione, Alessandra Pivari, Francesca Brasacchio, Caterina Barcella, Matteo Chittani, Martina D’Avila, Francesca Turiel, Maurizio Lazzaroni, Monica Soldati, Laura Cusi, Daniele Barlassina, Cristina J Transl Med Research BACKGROUND: Paraoxonase 1 (PON1) gene polymorphisms and polyphenols intake have been reported independently associated to lipid profile and susceptibility to atherosclerosis and cardiovascular disease. However, the interaction between these factors remains to be investigated. We performed an observational nutrigenetic study to examine whether the interaction between polyphenols and anthocyanins intake and PON1 genetic variants can modulate biomarkers of cardiovascular health in an Italian healthy population. METHODS: We recruited 443 healthy volunteers who participated in the EC funded ATHENA project (AnThocyanin and polyphenols bioactive for Health Enhancement through Nutritional Advancement). Data collection included detailed demographic, clinical, dietary, lifestyle, biochemical and genetic data. Polyphenols and anthocyanins intake was measured by 24 h dietary recall repeated three times a year in order to get seasonal variations. We tested the interaction between 18 independent tagging SNPs in PON1 gene and polyphenols intake on HDL, LDL, cholesterol, triglycerides and atherogenic index of plasma. RESULTS: Without considering the genetic background, we could not observe significant differences in the lipid profile between high and low polyphenols and anthocyanins intake. Using a nutrigenetic approach, we identified protective genotypes in four independent polymorphisms that, at Bonferroni level (p ≤ 0.0028), present a significant association with increased HDL level under high polyphenols and anthocyanins intake, compared to risk genotypes (rs854549, Beta = 4.7 per C allele; rs854552, Beta = 5.6 per C allele; rs854571, Beta = 3.92 per T allele; rs854572, Beta = 3.94 per C allele). CONCLUSIONS: We highlight the protective role of genetic variants in PON1 towards cardiovascular risk under high polyphenols and anthocyanins consumption. PON1 variants could represent novel biomarkers to stratify individuals who might benefit from targeted dietary recommendation for health promotion and strategies of preventive medicine. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12967-016-0941-6) contains supplementary material, which is available to authorized users. BioMed Central 2016-06-23 /pmc/articles/PMC4918189/ /pubmed/27338244 http://dx.doi.org/10.1186/s12967-016-0941-6 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Rizzi, Federica Conti, Costanza Dogliotti, Elena Terranegra, Annalisa Salvi, Erika Braga, Daniele Ricca, Flavia Lupoli, Sara Mingione, Alessandra Pivari, Francesca Brasacchio, Caterina Barcella, Matteo Chittani, Martina D’Avila, Francesca Turiel, Maurizio Lazzaroni, Monica Soldati, Laura Cusi, Daniele Barlassina, Cristina Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study |
title | Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study |
title_full | Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study |
title_fullStr | Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study |
title_full_unstemmed | Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study |
title_short | Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study |
title_sort | interaction between polyphenols intake and pon1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918189/ https://www.ncbi.nlm.nih.gov/pubmed/27338244 http://dx.doi.org/10.1186/s12967-016-0941-6 |
work_keys_str_mv | AT rizzifederica interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy AT conticostanza interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy AT dogliottielena interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy AT terranegraannalisa interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy AT salvierika interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy AT bragadaniele interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy AT riccaflavia interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy AT lupolisara interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy AT mingionealessandra interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy AT pivarifrancesca interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy AT brasacchiocaterina interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy AT barcellamatteo interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy AT chittanimartina interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy AT davilafrancesca interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy AT turielmaurizio interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy AT lazzaronimonica interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy AT soldatilaura interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy AT cusidaniele interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy AT barlassinacristina interactionbetweenpolyphenolsintakeandpon1genevariantsonmarkersofcardiovasculardiseaseanutrigeneticobservationalstudy |