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The environmental risk factors in multiple sclerosis susceptibility: A case-control study
BACKGROUND: Multiple sclerosis (MS) is a demyelinating and degenerating disease which involves central nervous system. Environmental risk factors have a key role in MS susceptibility. Here we aim to investigate different risk factors effect on MS susceptibility in a large population of MS patients i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918204/ https://www.ncbi.nlm.nih.gov/pubmed/27376037 http://dx.doi.org/10.4103/2277-9175.183665 |
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author | Shaygannejad, Vahid Rezaie, Nooshin Paknahad, Zamzam Ashtari, Freshteh Maghzi, Helia |
author_facet | Shaygannejad, Vahid Rezaie, Nooshin Paknahad, Zamzam Ashtari, Freshteh Maghzi, Helia |
author_sort | Shaygannejad, Vahid |
collection | PubMed |
description | BACKGROUND: Multiple sclerosis (MS) is a demyelinating and degenerating disease which involves central nervous system. Environmental risk factors have a key role in MS susceptibility. Here we aim to investigate different risk factors effect on MS susceptibility in a large population of MS patients in Isfahan, Iran. MATERIALS AND METHODS: This study is a cross-sectional hospital-based study, which was conducted on a large group of MS patients registered in Kashani hospital and a control group from normal healthy population. Demographic data, age at onset of the disease, history of viral infections, vaccination, history of trauma to head, recent stressful events, alimentation, familial history, method of delivery (caesarean section, normal vaginal delivery), disability score and history of smoking were gathered using a designed questionnaire. RESULTS: Totally 536 MS patient with the mean age of 34.37 ± 9.22 and 399 individuals from healthy population with the mean age of 32.53 ± 9.91 were recruited. Significant difference in history of measles infection (control = 15.5%, case = 22.4%, P = 0.009), consumption of dairy products (case = 56.6%, control = 67.5%, P = 0.01) and major stressful life events (case = 62.2%, control = 52.7%, P < 0.05) between these two groups were demonstrated. CONCLUSION: A significant relation between stress, history of infection and milk consumption was reached that highlights the importance of environmental risk factors in MS pathogenesis. |
format | Online Article Text |
id | pubmed-4918204 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-49182042016-07-01 The environmental risk factors in multiple sclerosis susceptibility: A case-control study Shaygannejad, Vahid Rezaie, Nooshin Paknahad, Zamzam Ashtari, Freshteh Maghzi, Helia Adv Biomed Res Original Article BACKGROUND: Multiple sclerosis (MS) is a demyelinating and degenerating disease which involves central nervous system. Environmental risk factors have a key role in MS susceptibility. Here we aim to investigate different risk factors effect on MS susceptibility in a large population of MS patients in Isfahan, Iran. MATERIALS AND METHODS: This study is a cross-sectional hospital-based study, which was conducted on a large group of MS patients registered in Kashani hospital and a control group from normal healthy population. Demographic data, age at onset of the disease, history of viral infections, vaccination, history of trauma to head, recent stressful events, alimentation, familial history, method of delivery (caesarean section, normal vaginal delivery), disability score and history of smoking were gathered using a designed questionnaire. RESULTS: Totally 536 MS patient with the mean age of 34.37 ± 9.22 and 399 individuals from healthy population with the mean age of 32.53 ± 9.91 were recruited. Significant difference in history of measles infection (control = 15.5%, case = 22.4%, P = 0.009), consumption of dairy products (case = 56.6%, control = 67.5%, P = 0.01) and major stressful life events (case = 62.2%, control = 52.7%, P < 0.05) between these two groups were demonstrated. CONCLUSION: A significant relation between stress, history of infection and milk consumption was reached that highlights the importance of environmental risk factors in MS pathogenesis. Medknow Publications & Media Pvt Ltd 2016-06-08 /pmc/articles/PMC4918204/ /pubmed/27376037 http://dx.doi.org/10.4103/2277-9175.183665 Text en Copyright: © 2016 Shaygannejad. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Original Article Shaygannejad, Vahid Rezaie, Nooshin Paknahad, Zamzam Ashtari, Freshteh Maghzi, Helia The environmental risk factors in multiple sclerosis susceptibility: A case-control study |
title | The environmental risk factors in multiple sclerosis susceptibility: A case-control study |
title_full | The environmental risk factors in multiple sclerosis susceptibility: A case-control study |
title_fullStr | The environmental risk factors in multiple sclerosis susceptibility: A case-control study |
title_full_unstemmed | The environmental risk factors in multiple sclerosis susceptibility: A case-control study |
title_short | The environmental risk factors in multiple sclerosis susceptibility: A case-control study |
title_sort | environmental risk factors in multiple sclerosis susceptibility: a case-control study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918204/ https://www.ncbi.nlm.nih.gov/pubmed/27376037 http://dx.doi.org/10.4103/2277-9175.183665 |
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