Current perspective on the role of the interleukin-23/interleukin-17 axis in inflammation and disease (chronic arthritis and psoriasis)

TH17 is a lymphocyte subset, which is characterized by its polarization to secrete interleukin (IL)-17. IL-23 is the pivotal mediator responsible for TH17 differentiation and the IL-23/IL-17 axis has been strongly implicated in the pathogenesis of several immune mediated diseases, in particular chro...

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Detalles Bibliográficos
Autores principales: Cauli, Alberto, Piga, Matteo, Floris, Alberto, Mathieu, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918258/
https://www.ncbi.nlm.nih.gov/pubmed/27471723
http://dx.doi.org/10.2147/ITT.S62870
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author Cauli, Alberto
Piga, Matteo
Floris, Alberto
Mathieu, Alessandro
author_facet Cauli, Alberto
Piga, Matteo
Floris, Alberto
Mathieu, Alessandro
author_sort Cauli, Alberto
collection PubMed
description TH17 is a lymphocyte subset, which is characterized by its polarization to secrete interleukin (IL)-17. IL-23 is the pivotal mediator responsible for TH17 differentiation and the IL-23/IL-17 axis has been strongly implicated in the pathogenesis of several immune mediated diseases, in particular chronic arthritis and skin psoriasis. This review will summarize the basic immunology and the new monoclonal antibodies, which antagonize this pathway allowing a new therapeutic approach.
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spelling pubmed-49182582016-07-28 Current perspective on the role of the interleukin-23/interleukin-17 axis in inflammation and disease (chronic arthritis and psoriasis) Cauli, Alberto Piga, Matteo Floris, Alberto Mathieu, Alessandro Immunotargets Ther Review TH17 is a lymphocyte subset, which is characterized by its polarization to secrete interleukin (IL)-17. IL-23 is the pivotal mediator responsible for TH17 differentiation and the IL-23/IL-17 axis has been strongly implicated in the pathogenesis of several immune mediated diseases, in particular chronic arthritis and skin psoriasis. This review will summarize the basic immunology and the new monoclonal antibodies, which antagonize this pathway allowing a new therapeutic approach. Dove Medical Press 2015-10-01 /pmc/articles/PMC4918258/ /pubmed/27471723 http://dx.doi.org/10.2147/ITT.S62870 Text en © 2015 Cauli et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Cauli, Alberto
Piga, Matteo
Floris, Alberto
Mathieu, Alessandro
Current perspective on the role of the interleukin-23/interleukin-17 axis in inflammation and disease (chronic arthritis and psoriasis)
title Current perspective on the role of the interleukin-23/interleukin-17 axis in inflammation and disease (chronic arthritis and psoriasis)
title_full Current perspective on the role of the interleukin-23/interleukin-17 axis in inflammation and disease (chronic arthritis and psoriasis)
title_fullStr Current perspective on the role of the interleukin-23/interleukin-17 axis in inflammation and disease (chronic arthritis and psoriasis)
title_full_unstemmed Current perspective on the role of the interleukin-23/interleukin-17 axis in inflammation and disease (chronic arthritis and psoriasis)
title_short Current perspective on the role of the interleukin-23/interleukin-17 axis in inflammation and disease (chronic arthritis and psoriasis)
title_sort current perspective on the role of the interleukin-23/interleukin-17 axis in inflammation and disease (chronic arthritis and psoriasis)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918258/
https://www.ncbi.nlm.nih.gov/pubmed/27471723
http://dx.doi.org/10.2147/ITT.S62870
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