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Emerging role of the peroxisome proliferator-activated receptor-gamma in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the major leading cause of cancer death worldwide. Hepatitis B virus, hepatitis C virus, alcohol consumption, non-alcoholic fatty liver disease, and diabetes are the major risks for developing HCC. Until now, recurrence and metastasis are the major cause of death in...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918273/ https://www.ncbi.nlm.nih.gov/pubmed/27508182 http://dx.doi.org/10.2147/JHC.S48512 |
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author | Hsu, Hui-Tzu Chi, Chin-Wen |
author_facet | Hsu, Hui-Tzu Chi, Chin-Wen |
author_sort | Hsu, Hui-Tzu |
collection | PubMed |
description | Hepatocellular carcinoma (HCC) is the major leading cause of cancer death worldwide. Hepatitis B virus, hepatitis C virus, alcohol consumption, non-alcoholic fatty liver disease, and diabetes are the major risks for developing HCC. Until now, recurrence and metastasis are the major cause of death in HCC patients. Therefore, identification of new effective molecular targets is an urgent need for treatment of HCC. Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated nuclear receptor which could be activated by PPARγ agonists such as thiazolidinediones, and natural PPARγ ligand (such as 15-deoxy-Δ12,14-prostaglandin J(2), 15d-PGJ(2)). Increasing in vitro and in vivo evidence has demonstrated that PPARγ agonists exhibit an inhibitory role on tumor cell growth, migration, and invasion, suggesting that PPARγ activation may play an important role in the regulation of growth of HCC. It has been reported that PPARγ activation by thiazolidinediones or overexpression of PPARγ by virus-mediated gene transfer has shown growth inhibitory effects in hepatoma cells, but the expression level of PPARγ in HCC tissues still remains conflicting. Notably, a novel PPARγ agonist, honokiol, has recently been found to activate the PPARγ/RXR heterodimer, and has also exhibited significant anti-cancer effects in hepatoma cells. In the present review, we summarized studies on the role and the molecular regulation of PPARγ in HCC development in vitro and in vivo. PPARγ has the potential to be a therapeutic target for future treatment of HCC. |
format | Online Article Text |
id | pubmed-4918273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-49182732016-08-09 Emerging role of the peroxisome proliferator-activated receptor-gamma in hepatocellular carcinoma Hsu, Hui-Tzu Chi, Chin-Wen J Hepatocell Carcinoma Review Hepatocellular carcinoma (HCC) is the major leading cause of cancer death worldwide. Hepatitis B virus, hepatitis C virus, alcohol consumption, non-alcoholic fatty liver disease, and diabetes are the major risks for developing HCC. Until now, recurrence and metastasis are the major cause of death in HCC patients. Therefore, identification of new effective molecular targets is an urgent need for treatment of HCC. Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated nuclear receptor which could be activated by PPARγ agonists such as thiazolidinediones, and natural PPARγ ligand (such as 15-deoxy-Δ12,14-prostaglandin J(2), 15d-PGJ(2)). Increasing in vitro and in vivo evidence has demonstrated that PPARγ agonists exhibit an inhibitory role on tumor cell growth, migration, and invasion, suggesting that PPARγ activation may play an important role in the regulation of growth of HCC. It has been reported that PPARγ activation by thiazolidinediones or overexpression of PPARγ by virus-mediated gene transfer has shown growth inhibitory effects in hepatoma cells, but the expression level of PPARγ in HCC tissues still remains conflicting. Notably, a novel PPARγ agonist, honokiol, has recently been found to activate the PPARγ/RXR heterodimer, and has also exhibited significant anti-cancer effects in hepatoma cells. In the present review, we summarized studies on the role and the molecular regulation of PPARγ in HCC development in vitro and in vivo. PPARγ has the potential to be a therapeutic target for future treatment of HCC. Dove Medical Press 2014-08-26 /pmc/articles/PMC4918273/ /pubmed/27508182 http://dx.doi.org/10.2147/JHC.S48512 Text en © 2014 Hsu and Chi. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Hsu, Hui-Tzu Chi, Chin-Wen Emerging role of the peroxisome proliferator-activated receptor-gamma in hepatocellular carcinoma |
title | Emerging role of the peroxisome proliferator-activated receptor-gamma in hepatocellular carcinoma |
title_full | Emerging role of the peroxisome proliferator-activated receptor-gamma in hepatocellular carcinoma |
title_fullStr | Emerging role of the peroxisome proliferator-activated receptor-gamma in hepatocellular carcinoma |
title_full_unstemmed | Emerging role of the peroxisome proliferator-activated receptor-gamma in hepatocellular carcinoma |
title_short | Emerging role of the peroxisome proliferator-activated receptor-gamma in hepatocellular carcinoma |
title_sort | emerging role of the peroxisome proliferator-activated receptor-gamma in hepatocellular carcinoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918273/ https://www.ncbi.nlm.nih.gov/pubmed/27508182 http://dx.doi.org/10.2147/JHC.S48512 |
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