PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation

Most tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and evade apoptosis. Intriguingly, the molecular mechanisms that link the Warburg effect with the suppression of apoptosis are not well understood. In this study, using loss-of-function studies in vitro and in v...

Descripción completa

Detalles Bibliográficos
Autores principales: Iansante, Valeria, Choy, Pui Man, Fung, Sze Wai, Liu, Ying, Chai, Jian-Guo, Dyson, Julian, Del Rio, Alberto, D'Santos, Clive, Williams, Roger, Chokshi, Shilpa, Anders, Robert A, Bubici, Concetta, Papa, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918319/
https://www.ncbi.nlm.nih.gov/pubmed/26258887
http://dx.doi.org/10.1038/ncomms8882

Ejemplares similares

Ejemplares similares