Cargando…

A C–H bond activation-based catalytic approach to tetrasubstituted chiral allenes

Enantioselective synthesis of fully substituted allenes has been a challenge due to the non-rigid nature of the axial chirality, which spreads over three carbon atoms. Here we show the commercially available simple Rh complex may catalyse the CMD (concerted metalation/deprotonation)-based reaction o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Shangze, Huang, Xin, Wu, Wangteng, Li, Pengbin, Fu, Chunling, Ma, Shengming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918348/ https://www.ncbi.nlm.nih.gov/pubmed/26246391 http://dx.doi.org/10.1038/ncomms8946

Ejemplares similares

Palladium-catalysed formation of vicinal all-carbon quaternary centres via propargylation
por: Huang, Xin, et al.
Publicado: (2016)

Catalytic enantioselective construction of axial chirality in 1,3-disubstituted allenes
por: Song, Shihua, et al.
Publicado: (2019)

Organocatalytic synthesis of chiral tetrasubstituted allenes from racemic propargylic alcohols
por: Qian, Deyun, et al.
Publicado: (2017)

Copper-catalyzed propargylic C–H functionalization for allene syntheses
por: Zhang, Dongjie, et al.
Publicado: (2023)

Rhodium-catalyzed C–H functionalization-based approach to eight-membered lactams
por: Wu, Shangze, et al.
Publicado: (2015)

A catalytic highly enantioselective allene approach to oxazolines
por: Luo, Hongwen, et al.
Publicado: (2018)

Benzene construction via Pd-catalyzed cyclization of 2,7-alkadiynylic carbonates in the presence of alkynes
por: Zhang, Yuchen, et al.
Publicado: (2018)

Stereoselectivity control in Rh-catalyzed β-OH elimination for chiral allene formation
por: Wang, Jie, et al.
Publicado: (2023)

Catalytic enantioselective allene–anhydride approach to β,γ-unsaturated enones bearing an α-all-carbon-quarternary center
por: Yuan, Yuan, et al.
Publicado: (2020)

A ruthenium(ii)-catalyzed C–H allenylation-based approach to allenoic acids
por: Wu, Xiaoyan, et al.
Publicado: (2019)

Catalytic enantioselective synthesis of tetrasubstituted chromanones via palladium-catalyzed asymmetric conjugate arylation using chiral pyridine-dihydroisoquinoline ligands
por: Baek, Doohyun, et al.
Publicado: (2020)

Synthesis of Di-, Tri-, and Tetrasubstituted Oxetanes by Rhodium-Catalyzed O=H Insertion and C=C Bond-Forming Cyclization**
por: Davis, Owen A, et al.
Publicado: (2014)

Pd/Xu-Phos-catalyzed asymmetric elimination of fully substituted enol triflates into axially chiral trisubstituted allenes
por: Han, Jie, et al.
Publicado: (2023)

Direct catalytic enantioselective amination of ketones for the formation of tri- and tetrasubstituted stereocenters
por: Trost, B. M., et al.
Publicado: (2018)

Photochemical Deracemization of Allenes and Subsequent Chirality Transfer
por: Plaza, Manuel, et al.
Publicado: (2020)

Unexpected chiral vicinal tetrasubstituted diamines via borylcopper-mediated homocoupling of isatin imines
por: Manenti, Marco, et al.
Publicado: (2022)

Enantiodivergent Synthesis of Allenes by Point‐to‐Axial Chirality Transfer
por: Armstrong, Roly J., et al.
Publicado: (2018)

Isomerization of Internal Alkynes to Iridium(III) Allene Complexes via C–H Bond Activation: Expanded Substrate Scope, and Progress towards a Catalytic Methodology
por: Phadke, Neha, et al.
Publicado: (2015)

Stereoselective Palladium-Catalyzed C–F Bond Alkenylation of Tetrasubstituted gem-Difluoroalkenes via Mizoroki–Heck Reaction
por: Wang, Yanhui, et al.
Publicado: (2023)

Enantioselective synthesis of α-tetrasubstituted (3-indolizinyl) (diaryl)methanamines via chiral phosphoric acid catalysis
por: Zhong, Jialing, et al.
Publicado: (2022)

Dual catalytic enantioselective desymmetrization of allene-tethered cyclohexanones
por: Zhang, Lin, et al.
Publicado: (2020)

Cobalt-catalyzed enantioselective C–H/N–H annulation of aryl sulfonamides with allenes or alkynes: facile access to C–N axially chiral sultams
por: Si, Xiao-Ju, et al.
Publicado: (2023)

Regio- and diastereoselective reactions of chiral secondary alkylcopper reagents with propargylic phosphates: preparation of chiral allenes
por: Skotnitzki, Juri, et al.
Publicado: (2020)

A Pd-catalyzed highly selective three-component protocol for trisubstituted allenes
por: Li, Can, et al.
Publicado: (2023)

Alkyne Aminopalladation/Heck and Suzuki Cascades: An Approach to Tetrasubstituted Enamines
por: Geffers, Finn J., et al.
Publicado: (2021)

Synthesis of new C(α)-tetrasubstituted α-amino acids
por: Grauer, Andreas A, et al.
Publicado: (2009)

Synthesis of Tetrasubstituted Alkenes via Metathesis
por: Paek, Seung-Mann
Publicado: (2012)

A palladium-catalyzed approach to allenic aromatic ethers and first total synthesis of terricollene A
por: Huang, Chaofan, et al.
Publicado: (2021)

Chirality Transfer in Gold(I)‐Catalysed Hydroalkoxylation of 1,3‐Disubstituted Allenes
por: Webster, Stacey, et al.
Publicado: (2016)

Enyne diketones as substrate in asymmetric Nazarov cyclization for construction of chiral allene cyclopentenones
por: Tang, Shengbiao, et al.
Publicado: (2022)

Access to a Catalytically Generated Umpolung Reagent through the Use of Cu-Catalyzed Reductive Coupling of Ketones and Allenes for the Synthesis of Chiral Vicinal Aminoalcohol Synthons
por: Gargaro, Samantha L., et al.
Publicado: (2019)

Catalytic atroposelective synthesis of axially chiral benzonitriles via chirality control during bond dissociation and CN group formation
por: Lv, Ya, et al.
Publicado: (2022)

Chiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies
por: Wang, Jiawen, et al.
Publicado: (2020)

Copper Hydride Catalyzed Enantioselective Synthesis of Axially Chiral 1,3-Disubstituted Allenes
por: Bayeh-Romero, Liela, et al.
Publicado: (2019)

Photo and copper dual catalysis for allene syntheses from propargylic derivatives via one-electron process
por: Liu, Qi, et al.
Publicado: (2022)

Synthesis of tetrasubstituted pyrazoles containing pyridinyl substituents
por: Jansa, Josef, et al.
Publicado: (2017)

Regio‐ and Stereoselective 1,2‐Oxyhalogenation of Non‐Conjugated Alkynes via Directed Nucleopalladation: Catalytic Access to Tetrasubstituted Alkenes
por: Liu, Mingyu, et al.
Publicado: (2022)

Nickel-catalysed asymmetric hydromonofluoromethylation of 1,3-enynes for enantioselective construction of monofluoromethyl-tethered chiral allenes
por: Zhang, Ying, et al.
Publicado: (2023)

Unveiling the Chemistry and Synthetic Potential of Catalytic Cycloaddition Reaction of Allenes: A Review
por: Sikandar, Sana, et al.
Publicado: (2023)

Asymmetric construction of pyrido[1,2-a]-1H-indole derivatives via a gold-catalyzed cycloisomerization
por: Jiang, Feng, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_otpnl1h8h0gquujlfkn6hkk9p1