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Clinical Features of Liver Cancer with Cerebral Hemorrhage

BACKGROUND: Cerebral hemorrhage is common in patients with cancer, but the clinical features and pathogenesis of liver cancer patients with cerebral hemorrhage are not well known. MATERIAL/METHODS: Liver cancer patients who developed cerebral hemorrhage were recruited from the First Affiliated Hospi...

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Autores principales: Lu, Qiuhong, Chen, Li, Zeng, Jinsheng, Huang, Gelun, Qin, Chao, Cheng, Daobin, Yu, Lixia, Liang, Zhijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918537/
https://www.ncbi.nlm.nih.gov/pubmed/27209058
http://dx.doi.org/10.12659/MSM.898642
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author Lu, Qiuhong
Chen, Li
Zeng, Jinsheng
Huang, Gelun
Qin, Chao
Cheng, Daobin
Yu, Lixia
Liang, Zhijian
author_facet Lu, Qiuhong
Chen, Li
Zeng, Jinsheng
Huang, Gelun
Qin, Chao
Cheng, Daobin
Yu, Lixia
Liang, Zhijian
author_sort Lu, Qiuhong
collection PubMed
description BACKGROUND: Cerebral hemorrhage is common in patients with cancer, but the clinical features and pathogenesis of liver cancer patients with cerebral hemorrhage are not well known. MATERIAL/METHODS: Liver cancer patients who developed cerebral hemorrhage were recruited from the First Affiliated Hospital of Guangxi Medical University between January 2003 and December 2014. We retrospectively analyzed clinical presentations, results of laboratory tests, and imaging examinations. The clinical features and pathogenesis were summarized. RESULTS: Among 11133 patients with liver cancer, 9 patients (0.08%), including 3 females and 6 males met the inclusion criteria. The age range was 48–73 years and the average age was 61.67±8.97 years. Five patients did not have traditional hemorrhage risk factors and 4s had the risk factors; however, all had developed hepatocellular carcinoma, and 3 had developed metastasis. All 9 patients showed elevated tumor markers: an increased AFP level was detected in 6 patients, coagulation dysfunctions in 8 patients, and abnormal liver functions in 6 patients. Five patients had developed cerebral hemorrhagic lesions in the lobes of their brains, while hemorrhagic lesions in the basal ganglia occurred in 3 patients and in the brainstem in only 1 patient. Four patients had clear consciousness, while 5 patients were in coma and showed poor prognosis. CONCLUSIONS: Patients who have liver cancer complicated with cerebral hemorrhage usually lack traditional risk factors of cerebral hemorrhage. The site of cerebral hemorrhage is often detected in the lobes of the brain. Coagulation dysfunctions might be the main pathogenesis of liver cancer complicated with cerebral hemorrhage.
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spelling pubmed-49185372016-06-30 Clinical Features of Liver Cancer with Cerebral Hemorrhage Lu, Qiuhong Chen, Li Zeng, Jinsheng Huang, Gelun Qin, Chao Cheng, Daobin Yu, Lixia Liang, Zhijian Med Sci Monit Clinical Research BACKGROUND: Cerebral hemorrhage is common in patients with cancer, but the clinical features and pathogenesis of liver cancer patients with cerebral hemorrhage are not well known. MATERIAL/METHODS: Liver cancer patients who developed cerebral hemorrhage were recruited from the First Affiliated Hospital of Guangxi Medical University between January 2003 and December 2014. We retrospectively analyzed clinical presentations, results of laboratory tests, and imaging examinations. The clinical features and pathogenesis were summarized. RESULTS: Among 11133 patients with liver cancer, 9 patients (0.08%), including 3 females and 6 males met the inclusion criteria. The age range was 48–73 years and the average age was 61.67±8.97 years. Five patients did not have traditional hemorrhage risk factors and 4s had the risk factors; however, all had developed hepatocellular carcinoma, and 3 had developed metastasis. All 9 patients showed elevated tumor markers: an increased AFP level was detected in 6 patients, coagulation dysfunctions in 8 patients, and abnormal liver functions in 6 patients. Five patients had developed cerebral hemorrhagic lesions in the lobes of their brains, while hemorrhagic lesions in the basal ganglia occurred in 3 patients and in the brainstem in only 1 patient. Four patients had clear consciousness, while 5 patients were in coma and showed poor prognosis. CONCLUSIONS: Patients who have liver cancer complicated with cerebral hemorrhage usually lack traditional risk factors of cerebral hemorrhage. The site of cerebral hemorrhage is often detected in the lobes of the brain. Coagulation dysfunctions might be the main pathogenesis of liver cancer complicated with cerebral hemorrhage. International Scientific Literature, Inc. 2016-05-22 /pmc/articles/PMC4918537/ /pubmed/27209058 http://dx.doi.org/10.12659/MSM.898642 Text en © Med Sci Monit, 2016 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
spellingShingle Clinical Research
Lu, Qiuhong
Chen, Li
Zeng, Jinsheng
Huang, Gelun
Qin, Chao
Cheng, Daobin
Yu, Lixia
Liang, Zhijian
Clinical Features of Liver Cancer with Cerebral Hemorrhage
title Clinical Features of Liver Cancer with Cerebral Hemorrhage
title_full Clinical Features of Liver Cancer with Cerebral Hemorrhage
title_fullStr Clinical Features of Liver Cancer with Cerebral Hemorrhage
title_full_unstemmed Clinical Features of Liver Cancer with Cerebral Hemorrhage
title_short Clinical Features of Liver Cancer with Cerebral Hemorrhage
title_sort clinical features of liver cancer with cerebral hemorrhage
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918537/
https://www.ncbi.nlm.nih.gov/pubmed/27209058
http://dx.doi.org/10.12659/MSM.898642
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