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Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress

Recent evidence has exhibited dietary influence on the manifestation of different types of behavior induced by stressor tasks. The present study examined the effects of Tualang honey supplement administered with the goal of preventing or attenuating the occurrence of stress-related behaviors in male...

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Autores principales: Azman, Khairunnuur Fairuz, Zakaria, Rahimah, AbdAziz, CheBadariah, Othman, Zahiruddin, Al-Rahbi, Badriya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918659/
https://www.ncbi.nlm.nih.gov/pubmed/25774610
http://dx.doi.org/10.4103/1463-1741.153388
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author Azman, Khairunnuur Fairuz
Zakaria, Rahimah
AbdAziz, CheBadariah
Othman, Zahiruddin
Al-Rahbi, Badriya
author_facet Azman, Khairunnuur Fairuz
Zakaria, Rahimah
AbdAziz, CheBadariah
Othman, Zahiruddin
Al-Rahbi, Badriya
author_sort Azman, Khairunnuur Fairuz
collection PubMed
description Recent evidence has exhibited dietary influence on the manifestation of different types of behavior induced by stressor tasks. The present study examined the effects of Tualang honey supplement administered with the goal of preventing or attenuating the occurrence of stress-related behaviors in male rats subjected to noise stress. Forty-eight adult male rats were randomly divided into the following four groups: i) nonstressed with vehicle, ii) nonstressed with Tualang honey, iii) stressed with vehicle, and iv) stressed with honey. The supplement was given once daily via oral gavage at 0.2 g/kg body weight. Two types of behavioral tests were performed, namely, the novel object recognition test to evaluate working memory and the forced swimming test to evaluate depressive-like behavior. Data were analyzed by a two-way analysis of variance (ANOVA) using IBM SPSS 18.0. It was observed that the rats subjected to noise stress expressed higher levels of depressive-like behavior and lower memory functions compared to the unexposed control rats. In addition, our results indicated that the supplementation regimen successfully counteracted the effects of noise stress. The forced swimming test indicated that climbing and swimming times were significantly increased and immobility times significantly decreased in honey-supplemented rats, thereby demonstrating an antidepressant-like effect. Furthermore, cognitive function was shown to be intensely affected by noise stress, but the effects were counteracted by the honey supplement. These findings suggest that subchronic exposure to noise stress induces depressive-like behavior and reduces cognitive functions, and that these effects can be attenuated by Tualang honey supplementation. This warrants further studies to examine the role of Tulang honey in mediating such effects.
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spelling pubmed-49186592016-07-14 Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress Azman, Khairunnuur Fairuz Zakaria, Rahimah AbdAziz, CheBadariah Othman, Zahiruddin Al-Rahbi, Badriya Noise Health Original Article Recent evidence has exhibited dietary influence on the manifestation of different types of behavior induced by stressor tasks. The present study examined the effects of Tualang honey supplement administered with the goal of preventing or attenuating the occurrence of stress-related behaviors in male rats subjected to noise stress. Forty-eight adult male rats were randomly divided into the following four groups: i) nonstressed with vehicle, ii) nonstressed with Tualang honey, iii) stressed with vehicle, and iv) stressed with honey. The supplement was given once daily via oral gavage at 0.2 g/kg body weight. Two types of behavioral tests were performed, namely, the novel object recognition test to evaluate working memory and the forced swimming test to evaluate depressive-like behavior. Data were analyzed by a two-way analysis of variance (ANOVA) using IBM SPSS 18.0. It was observed that the rats subjected to noise stress expressed higher levels of depressive-like behavior and lower memory functions compared to the unexposed control rats. In addition, our results indicated that the supplementation regimen successfully counteracted the effects of noise stress. The forced swimming test indicated that climbing and swimming times were significantly increased and immobility times significantly decreased in honey-supplemented rats, thereby demonstrating an antidepressant-like effect. Furthermore, cognitive function was shown to be intensely affected by noise stress, but the effects were counteracted by the honey supplement. These findings suggest that subchronic exposure to noise stress induces depressive-like behavior and reduces cognitive functions, and that these effects can be attenuated by Tualang honey supplementation. This warrants further studies to examine the role of Tulang honey in mediating such effects. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4918659/ /pubmed/25774610 http://dx.doi.org/10.4103/1463-1741.153388 Text en Copyright: © 2015 Noise & Health http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Azman, Khairunnuur Fairuz
Zakaria, Rahimah
AbdAziz, CheBadariah
Othman, Zahiruddin
Al-Rahbi, Badriya
Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress
title Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress
title_full Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress
title_fullStr Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress
title_full_unstemmed Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress
title_short Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress
title_sort tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918659/
https://www.ncbi.nlm.nih.gov/pubmed/25774610
http://dx.doi.org/10.4103/1463-1741.153388
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