Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity

ADARs (adenosine deaminases acting on RNA) are editing enzymes that convert adenosine (A) to inosine (I) in duplex RNA, a modification reaction with wide-ranging consequences on RNA function. Our understanding of the ADAR reaction mechanism, origin of editing site selectivity and effect of mutations...

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Detalles Bibliográficos
Autores principales: Matthews, Melissa M., Thomas, Justin M., Zheng, Yuxuan, Tran, Kiet, Phelps, Kelly J., Scott, Anna I., Havel, Jocelyn, Fisher, Andrew J., Beal, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918759/
https://www.ncbi.nlm.nih.gov/pubmed/27065196
http://dx.doi.org/10.1038/nsmb.3203

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