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The Popeye Domain Containing Genes and Their Function in Striated Muscle
The Popeye domain containing (POPDC) genes encode a novel class of cAMP effector proteins, which are abundantly expressed in heart and skeletal muscle. Here, we will review their role in striated muscle as deduced from work in cell and animal models and the recent analysis of patients carrying a mis...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918794/ https://www.ncbi.nlm.nih.gov/pubmed/27347491 http://dx.doi.org/10.3390/jcdd3020022 |
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author | Schindler, Roland F. R. Scotton, Chiara French, Vanessa Ferlini, Alessandra Brand, Thomas |
author_facet | Schindler, Roland F. R. Scotton, Chiara French, Vanessa Ferlini, Alessandra Brand, Thomas |
author_sort | Schindler, Roland F. R. |
collection | PubMed |
description | The Popeye domain containing (POPDC) genes encode a novel class of cAMP effector proteins, which are abundantly expressed in heart and skeletal muscle. Here, we will review their role in striated muscle as deduced from work in cell and animal models and the recent analysis of patients carrying a missense mutation in POPDC1. Evidence suggests that POPDC proteins control membrane trafficking of interacting proteins. Furthermore, we will discuss the current catalogue of established protein-protein interactions. In recent years, the number of POPDC-interacting proteins has been rising and currently includes ion channels (TREK-1), sarcolemma-associated proteins serving functions in mechanical stability (dystrophin), compartmentalization (caveolin 3), scaffolding (ZO-1), trafficking (NDRG4, VAMP2/3) and repair (dysferlin) or acting as a guanine nucleotide exchange factor for Rho-family GTPases (GEFT). Recent evidence suggests that POPDC proteins might also control the cellular level of the nuclear proto-oncoprotein c-Myc. These data suggest that this family of cAMP-binding proteins probably serves multiple roles in striated muscle. |
format | Online Article Text |
id | pubmed-4918794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-49187942016-06-23 The Popeye Domain Containing Genes and Their Function in Striated Muscle Schindler, Roland F. R. Scotton, Chiara French, Vanessa Ferlini, Alessandra Brand, Thomas J Cardiovasc Dev Dis Review The Popeye domain containing (POPDC) genes encode a novel class of cAMP effector proteins, which are abundantly expressed in heart and skeletal muscle. Here, we will review their role in striated muscle as deduced from work in cell and animal models and the recent analysis of patients carrying a missense mutation in POPDC1. Evidence suggests that POPDC proteins control membrane trafficking of interacting proteins. Furthermore, we will discuss the current catalogue of established protein-protein interactions. In recent years, the number of POPDC-interacting proteins has been rising and currently includes ion channels (TREK-1), sarcolemma-associated proteins serving functions in mechanical stability (dystrophin), compartmentalization (caveolin 3), scaffolding (ZO-1), trafficking (NDRG4, VAMP2/3) and repair (dysferlin) or acting as a guanine nucleotide exchange factor for Rho-family GTPases (GEFT). Recent evidence suggests that POPDC proteins might also control the cellular level of the nuclear proto-oncoprotein c-Myc. These data suggest that this family of cAMP-binding proteins probably serves multiple roles in striated muscle. MDPI 2016-06-15 /pmc/articles/PMC4918794/ /pubmed/27347491 http://dx.doi.org/10.3390/jcdd3020022 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Schindler, Roland F. R. Scotton, Chiara French, Vanessa Ferlini, Alessandra Brand, Thomas The Popeye Domain Containing Genes and Their Function in Striated Muscle |
title | The Popeye Domain Containing Genes and Their Function in Striated Muscle |
title_full | The Popeye Domain Containing Genes and Their Function in Striated Muscle |
title_fullStr | The Popeye Domain Containing Genes and Their Function in Striated Muscle |
title_full_unstemmed | The Popeye Domain Containing Genes and Their Function in Striated Muscle |
title_short | The Popeye Domain Containing Genes and Their Function in Striated Muscle |
title_sort | popeye domain containing genes and their function in striated muscle |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918794/ https://www.ncbi.nlm.nih.gov/pubmed/27347491 http://dx.doi.org/10.3390/jcdd3020022 |
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