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The Popeye Domain Containing Genes and Their Function in Striated Muscle

The Popeye domain containing (POPDC) genes encode a novel class of cAMP effector proteins, which are abundantly expressed in heart and skeletal muscle. Here, we will review their role in striated muscle as deduced from work in cell and animal models and the recent analysis of patients carrying a mis...

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Autores principales: Schindler, Roland F. R., Scotton, Chiara, French, Vanessa, Ferlini, Alessandra, Brand, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918794/
https://www.ncbi.nlm.nih.gov/pubmed/27347491
http://dx.doi.org/10.3390/jcdd3020022
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author Schindler, Roland F. R.
Scotton, Chiara
French, Vanessa
Ferlini, Alessandra
Brand, Thomas
author_facet Schindler, Roland F. R.
Scotton, Chiara
French, Vanessa
Ferlini, Alessandra
Brand, Thomas
author_sort Schindler, Roland F. R.
collection PubMed
description The Popeye domain containing (POPDC) genes encode a novel class of cAMP effector proteins, which are abundantly expressed in heart and skeletal muscle. Here, we will review their role in striated muscle as deduced from work in cell and animal models and the recent analysis of patients carrying a missense mutation in POPDC1. Evidence suggests that POPDC proteins control membrane trafficking of interacting proteins. Furthermore, we will discuss the current catalogue of established protein-protein interactions. In recent years, the number of POPDC-interacting proteins has been rising and currently includes ion channels (TREK-1), sarcolemma-associated proteins serving functions in mechanical stability (dystrophin), compartmentalization (caveolin 3), scaffolding (ZO-1), trafficking (NDRG4, VAMP2/3) and repair (dysferlin) or acting as a guanine nucleotide exchange factor for Rho-family GTPases (GEFT). Recent evidence suggests that POPDC proteins might also control the cellular level of the nuclear proto-oncoprotein c-Myc. These data suggest that this family of cAMP-binding proteins probably serves multiple roles in striated muscle.
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spelling pubmed-49187942016-06-23 The Popeye Domain Containing Genes and Their Function in Striated Muscle Schindler, Roland F. R. Scotton, Chiara French, Vanessa Ferlini, Alessandra Brand, Thomas J Cardiovasc Dev Dis Review The Popeye domain containing (POPDC) genes encode a novel class of cAMP effector proteins, which are abundantly expressed in heart and skeletal muscle. Here, we will review their role in striated muscle as deduced from work in cell and animal models and the recent analysis of patients carrying a missense mutation in POPDC1. Evidence suggests that POPDC proteins control membrane trafficking of interacting proteins. Furthermore, we will discuss the current catalogue of established protein-protein interactions. In recent years, the number of POPDC-interacting proteins has been rising and currently includes ion channels (TREK-1), sarcolemma-associated proteins serving functions in mechanical stability (dystrophin), compartmentalization (caveolin 3), scaffolding (ZO-1), trafficking (NDRG4, VAMP2/3) and repair (dysferlin) or acting as a guanine nucleotide exchange factor for Rho-family GTPases (GEFT). Recent evidence suggests that POPDC proteins might also control the cellular level of the nuclear proto-oncoprotein c-Myc. These data suggest that this family of cAMP-binding proteins probably serves multiple roles in striated muscle. MDPI 2016-06-15 /pmc/articles/PMC4918794/ /pubmed/27347491 http://dx.doi.org/10.3390/jcdd3020022 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schindler, Roland F. R.
Scotton, Chiara
French, Vanessa
Ferlini, Alessandra
Brand, Thomas
The Popeye Domain Containing Genes and Their Function in Striated Muscle
title The Popeye Domain Containing Genes and Their Function in Striated Muscle
title_full The Popeye Domain Containing Genes and Their Function in Striated Muscle
title_fullStr The Popeye Domain Containing Genes and Their Function in Striated Muscle
title_full_unstemmed The Popeye Domain Containing Genes and Their Function in Striated Muscle
title_short The Popeye Domain Containing Genes and Their Function in Striated Muscle
title_sort popeye domain containing genes and their function in striated muscle
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918794/
https://www.ncbi.nlm.nih.gov/pubmed/27347491
http://dx.doi.org/10.3390/jcdd3020022
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