Medicinal chemistry of cannabinoids

The endocannabinoid system comprises the two well characterized G(i/o)‐protein coupled receptors (cannabinoid receptor 1 (CB1) and CB2), their endogenous lipid ligands, and the enzymes involved in their biosynthesis and biotransformation. Drug discovery efforts relating to the endocannabinoid system...

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Detalles Bibliográficos
Autores principales: Vemuri, V Kiran, Makriyannis, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Translation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918805/
https://www.ncbi.nlm.nih.gov/pubmed/25801236
http://dx.doi.org/10.1002/cpt.115
Descripción
Sumario:The endocannabinoid system comprises the two well characterized G(i/o)‐protein coupled receptors (cannabinoid receptor 1 (CB1) and CB2), their endogenous lipid ligands, and the enzymes involved in their biosynthesis and biotransformation. Drug discovery efforts relating to the endocannabinoid system have been focused mainly on the two cannabinoid receptors and the two endocannabinoid deactivating enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL). This review provides an overview of cannabinergic agents used in drug research and those being explored clinically.

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