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Medicinal chemistry of cannabinoids

The endocannabinoid system comprises the two well characterized G(i/o)‐protein coupled receptors (cannabinoid receptor 1 (CB1) and CB2), their endogenous lipid ligands, and the enzymes involved in their biosynthesis and biotransformation. Drug discovery efforts relating to the endocannabinoid system...

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Detalles Bibliográficos
Autores principales: Vemuri, V Kiran, Makriyannis, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918805/
https://www.ncbi.nlm.nih.gov/pubmed/25801236
http://dx.doi.org/10.1002/cpt.115
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author Vemuri, V Kiran
Makriyannis, A
author_facet Vemuri, V Kiran
Makriyannis, A
author_sort Vemuri, V Kiran
collection PubMed
description The endocannabinoid system comprises the two well characterized G(i/o)‐protein coupled receptors (cannabinoid receptor 1 (CB1) and CB2), their endogenous lipid ligands, and the enzymes involved in their biosynthesis and biotransformation. Drug discovery efforts relating to the endocannabinoid system have been focused mainly on the two cannabinoid receptors and the two endocannabinoid deactivating enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL). This review provides an overview of cannabinergic agents used in drug research and those being explored clinically.
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spelling pubmed-49188052016-06-23 Medicinal chemistry of cannabinoids Vemuri, V Kiran Makriyannis, A Clin Pharmacol Ther Translation The endocannabinoid system comprises the two well characterized G(i/o)‐protein coupled receptors (cannabinoid receptor 1 (CB1) and CB2), their endogenous lipid ligands, and the enzymes involved in their biosynthesis and biotransformation. Drug discovery efforts relating to the endocannabinoid system have been focused mainly on the two cannabinoid receptors and the two endocannabinoid deactivating enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL). This review provides an overview of cannabinergic agents used in drug research and those being explored clinically. John Wiley and Sons Inc. 2015-04-16 2015-06 /pmc/articles/PMC4918805/ /pubmed/25801236 http://dx.doi.org/10.1002/cpt.115 Text en © 2015 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of The American Society for Clinical Pharmacology and Therapeutics. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Translation
Vemuri, V Kiran
Makriyannis, A
Medicinal chemistry of cannabinoids
title Medicinal chemistry of cannabinoids
title_full Medicinal chemistry of cannabinoids
title_fullStr Medicinal chemistry of cannabinoids
title_full_unstemmed Medicinal chemistry of cannabinoids
title_short Medicinal chemistry of cannabinoids
title_sort medicinal chemistry of cannabinoids
topic Translation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918805/
https://www.ncbi.nlm.nih.gov/pubmed/25801236
http://dx.doi.org/10.1002/cpt.115
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