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Medicinal chemistry of cannabinoids
The endocannabinoid system comprises the two well characterized G(i/o)‐protein coupled receptors (cannabinoid receptor 1 (CB1) and CB2), their endogenous lipid ligands, and the enzymes involved in their biosynthesis and biotransformation. Drug discovery efforts relating to the endocannabinoid system...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918805/ https://www.ncbi.nlm.nih.gov/pubmed/25801236 http://dx.doi.org/10.1002/cpt.115 |
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author | Vemuri, V Kiran Makriyannis, A |
author_facet | Vemuri, V Kiran Makriyannis, A |
author_sort | Vemuri, V Kiran |
collection | PubMed |
description | The endocannabinoid system comprises the two well characterized G(i/o)‐protein coupled receptors (cannabinoid receptor 1 (CB1) and CB2), their endogenous lipid ligands, and the enzymes involved in their biosynthesis and biotransformation. Drug discovery efforts relating to the endocannabinoid system have been focused mainly on the two cannabinoid receptors and the two endocannabinoid deactivating enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL). This review provides an overview of cannabinergic agents used in drug research and those being explored clinically. |
format | Online Article Text |
id | pubmed-4918805 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-49188052016-06-23 Medicinal chemistry of cannabinoids Vemuri, V Kiran Makriyannis, A Clin Pharmacol Ther Translation The endocannabinoid system comprises the two well characterized G(i/o)‐protein coupled receptors (cannabinoid receptor 1 (CB1) and CB2), their endogenous lipid ligands, and the enzymes involved in their biosynthesis and biotransformation. Drug discovery efforts relating to the endocannabinoid system have been focused mainly on the two cannabinoid receptors and the two endocannabinoid deactivating enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL). This review provides an overview of cannabinergic agents used in drug research and those being explored clinically. John Wiley and Sons Inc. 2015-04-16 2015-06 /pmc/articles/PMC4918805/ /pubmed/25801236 http://dx.doi.org/10.1002/cpt.115 Text en © 2015 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of The American Society for Clinical Pharmacology and Therapeutics. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Translation Vemuri, V Kiran Makriyannis, A Medicinal chemistry of cannabinoids |
title | Medicinal chemistry of cannabinoids |
title_full | Medicinal chemistry of cannabinoids |
title_fullStr | Medicinal chemistry of cannabinoids |
title_full_unstemmed | Medicinal chemistry of cannabinoids |
title_short | Medicinal chemistry of cannabinoids |
title_sort | medicinal chemistry of cannabinoids |
topic | Translation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918805/ https://www.ncbi.nlm.nih.gov/pubmed/25801236 http://dx.doi.org/10.1002/cpt.115 |
work_keys_str_mv | AT vemurivkiran medicinalchemistryofcannabinoids AT makriyannisa medicinalchemistryofcannabinoids |