Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity α4β2, and Increases α5α4β2, Nicotinic Receptor Surface Expression

A number of mutations in α4β2-containing (α4β2*) nicotinic acetylcholine (ACh) receptors (nAChRs) are linked to autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), including one in the β2 subunit called β2V287L. Two α4β2* subtypes with different subunit stoichiometries and ACh sensitivities...

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Detalles Bibliográficos
Autores principales: Nichols, Weston A., Henderson, Brandon J., Marotta, Christopher B., Yu, Caroline Y., Richards, Chris, Dougherty, Dennis A., Lester, Henry A., Cohen, Bruce N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918917/
https://www.ncbi.nlm.nih.gov/pubmed/27336596
http://dx.doi.org/10.1371/journal.pone.0158032

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