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The Ensembl gene annotation system
The Ensembl gene annotation system has been used to annotate over 70 different vertebrate species across a wide range of genome projects. Furthermore, it generates the automatic alignment-based annotation for the human and mouse GENCODE gene sets. The system is based on the alignment of biological s...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919035/ https://www.ncbi.nlm.nih.gov/pubmed/27337980 http://dx.doi.org/10.1093/database/baw093 |
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| author | Aken, Bronwen L. Ayling, Sarah Barrell, Daniel Clarke, Laura Curwen, Valery Fairley, Susan Fernandez Banet, Julio Billis, Konstantinos García Girón, Carlos Hourlier, Thibaut Howe, Kevin Kähäri, Andreas Kokocinski, Felix Martin, Fergal J. Murphy, Daniel N. Nag, Rishi Ruffier, Magali Schuster, Michael Tang, Y. Amy Vogel, Jan-Hinnerk White, Simon Zadissa, Amonida Flicek, Paul Searle, Stephen M. J. |
| author_facet | Aken, Bronwen L. Ayling, Sarah Barrell, Daniel Clarke, Laura Curwen, Valery Fairley, Susan Fernandez Banet, Julio Billis, Konstantinos García Girón, Carlos Hourlier, Thibaut Howe, Kevin Kähäri, Andreas Kokocinski, Felix Martin, Fergal J. Murphy, Daniel N. Nag, Rishi Ruffier, Magali Schuster, Michael Tang, Y. Amy Vogel, Jan-Hinnerk White, Simon Zadissa, Amonida Flicek, Paul Searle, Stephen M. J. |
| author_sort | Aken, Bronwen L. |
| collection | PubMed |
| description | The Ensembl gene annotation system has been used to annotate over 70 different vertebrate species across a wide range of genome projects. Furthermore, it generates the automatic alignment-based annotation for the human and mouse GENCODE gene sets. The system is based on the alignment of biological sequences, including cDNAs, proteins and RNA-seq reads, to the target genome in order to construct candidate transcript models. Careful assessment and filtering of these candidate transcripts ultimately leads to the final gene set, which is made available on the Ensembl website. Here, we describe the annotation process in detail. Database URL: http://www.ensembl.org/index.html |
| format | Online Article Text |
| id | pubmed-4919035 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-49190352016-06-24 The Ensembl gene annotation system Aken, Bronwen L. Ayling, Sarah Barrell, Daniel Clarke, Laura Curwen, Valery Fairley, Susan Fernandez Banet, Julio Billis, Konstantinos García Girón, Carlos Hourlier, Thibaut Howe, Kevin Kähäri, Andreas Kokocinski, Felix Martin, Fergal J. Murphy, Daniel N. Nag, Rishi Ruffier, Magali Schuster, Michael Tang, Y. Amy Vogel, Jan-Hinnerk White, Simon Zadissa, Amonida Flicek, Paul Searle, Stephen M. J. Database (Oxford) Database Update The Ensembl gene annotation system has been used to annotate over 70 different vertebrate species across a wide range of genome projects. Furthermore, it generates the automatic alignment-based annotation for the human and mouse GENCODE gene sets. The system is based on the alignment of biological sequences, including cDNAs, proteins and RNA-seq reads, to the target genome in order to construct candidate transcript models. Careful assessment and filtering of these candidate transcripts ultimately leads to the final gene set, which is made available on the Ensembl website. Here, we describe the annotation process in detail. Database URL: http://www.ensembl.org/index.html Oxford University Press 2016-06-23 /pmc/articles/PMC4919035/ /pubmed/27337980 http://dx.doi.org/10.1093/database/baw093 Text en © The Author(s) 2016. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Database Update Aken, Bronwen L. Ayling, Sarah Barrell, Daniel Clarke, Laura Curwen, Valery Fairley, Susan Fernandez Banet, Julio Billis, Konstantinos García Girón, Carlos Hourlier, Thibaut Howe, Kevin Kähäri, Andreas Kokocinski, Felix Martin, Fergal J. Murphy, Daniel N. Nag, Rishi Ruffier, Magali Schuster, Michael Tang, Y. Amy Vogel, Jan-Hinnerk White, Simon Zadissa, Amonida Flicek, Paul Searle, Stephen M. J. The Ensembl gene annotation system |
| title | The Ensembl gene annotation system |
| title_full | The Ensembl gene annotation system |
| title_fullStr | The Ensembl gene annotation system |
| title_full_unstemmed | The Ensembl gene annotation system |
| title_short | The Ensembl gene annotation system |
| title_sort | ensembl gene annotation system |
| topic | Database Update |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919035/ https://www.ncbi.nlm.nih.gov/pubmed/27337980 http://dx.doi.org/10.1093/database/baw093 |
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