Novel Clostridium difficile Anti-Toxin (TcdA and TcdB) Humanized Monoclonal Antibodies Demonstrate In Vitro Neutralization across a Broad Spectrum of Clinical Strains and In Vivo Potency in a Hamster Spore Challenge Model

Clostridium difficile (C. difficile) infection (CDI) is the main cause of nosocomial antibiotic-associated colitis and increased incidence of community-associated diarrhea in industrialized countries. At present, the primary treatment of CDI is antibiotic administration, which is effective but often...

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Detalles Bibliográficos
Autores principales: Qiu, Hongyu, Cassan, Robyn, Johnstone, Darrell, Han, Xiaobing, Joyee, Antony George, McQuoid, Monica, Masi, Andrea, Merluza, John, Hrehorak, Bryce, Reid, Ross, Kennedy, Kieron, Tighe, Bonnie, Rak, Carla, Leonhardt, Melanie, Dupas, Brian, Saward, Laura, Berry, Jody D., Nykiforuk, Cory L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919053/
https://www.ncbi.nlm.nih.gov/pubmed/27336843
http://dx.doi.org/10.1371/journal.pone.0157970

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