Selective spider toxins reveal a role for Na(v)1.1 channel in mechanical pain

Voltage-gated sodium (Na(v)) channels initiate action potentials in most neurons, including primary afferent nerve fibers of the pain pathway. Local anesthetics block pain through non-specific actions at all Na(v) channels, but the discovery of selective modulators would facilitate the analysis of i...

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Detalles Bibliográficos
Autores principales: Osteen, Jeremiah D., Herzig, Volker, Gilchrist, John, Emrick, Joshua J., Zhang, Chuchu, Wang, Xidao, Castro, Joel, Garcia-Caraballo, Sonia, Grundy, Luke, Rychkov, Grigori Y., Weyer, Andy D., Dekan, Zoltan, Undheim, Eivind A. B., Alewood, Paul, Stucky, Cheryl L., Brierley, Stuart M., Basbaum, Allan I., Bosmans, Frank, King, Glenn F., Julius, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919188/
https://www.ncbi.nlm.nih.gov/pubmed/27281198
http://dx.doi.org/10.1038/nature17976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919188/
https://www.ncbi.nlm.nih.gov/pubmed/27281198
http://dx.doi.org/10.1038/nature17976

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