Supplementation of host response by targeting nitric oxide to the macrophage cytosol is efficacious in the hamster model of visceral leishmaniasis and adds to efficacy of amphotericin B

We investigated efficacy of nitric oxide (NO) against Leishmania donovani. NO is a mediator of host response to infection, with direct parasiticidal activity in addition to its role in signalling to evoke innate macrophage responses. However, it is short-lived and volatile, and is therefore difficul...

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Detalles Bibliográficos
Autores principales: Pandya, Sanketkumar, Verma, Rahul Kumar, Khare, Prashant, Tiwari, Brajendra, Srinivasarao, Dadi A., Dube, Anuradha, Goyal, Neena, Misra, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919251/
https://www.ncbi.nlm.nih.gov/pubmed/27183429
http://dx.doi.org/10.1016/j.ijpddr.2016.01.001

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