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Canine Detection of the Volatilome: A Review of Implications for Pathogen and Disease Detection

The volatilome is the entire set of volatile organic compounds (VOC) produced by an organism. The accumulation of VOC inside and outside of the body reflects the unique metabolic state of an organism. Scientists are developing technologies to non-invasively detect VOC for the purposes of medical dia...

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Autores principales: Angle, Craig, Waggoner, Lowell Paul, Ferrando, Arny, Haney, Pamela, Passler, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919317/
https://www.ncbi.nlm.nih.gov/pubmed/27446935
http://dx.doi.org/10.3389/fvets.2016.00047
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author Angle, Craig
Waggoner, Lowell Paul
Ferrando, Arny
Haney, Pamela
Passler, Thomas
author_facet Angle, Craig
Waggoner, Lowell Paul
Ferrando, Arny
Haney, Pamela
Passler, Thomas
author_sort Angle, Craig
collection PubMed
description The volatilome is the entire set of volatile organic compounds (VOC) produced by an organism. The accumulation of VOC inside and outside of the body reflects the unique metabolic state of an organism. Scientists are developing technologies to non-invasively detect VOC for the purposes of medical diagnosis, therapeutic monitoring, disease outbreak containment, and disease prevention. Detection dogs are proven to be a valuable real-time mobile detection technology for the detection of VOC related to explosives, narcotics, humans, and many other targets of interests. Little is known about what dogs are detecting when searching for biological targets. It is important to understand where biological VOC originates and how dogs might be able to detect biological targets. This review paper discusses the recent scientific literature involving VOC analysis and postulates potential biological targets for canine detection. Dogs have shown their ability to detect pathogen and disease-specific VOC. Future research will determine if dogs can be employed operationally in hospitals, on borders, in underserved areas, on farms, and in other operational environments to give real-time feedback on the presence of a biological target.
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spelling pubmed-49193172016-07-21 Canine Detection of the Volatilome: A Review of Implications for Pathogen and Disease Detection Angle, Craig Waggoner, Lowell Paul Ferrando, Arny Haney, Pamela Passler, Thomas Front Vet Sci Veterinary Science The volatilome is the entire set of volatile organic compounds (VOC) produced by an organism. The accumulation of VOC inside and outside of the body reflects the unique metabolic state of an organism. Scientists are developing technologies to non-invasively detect VOC for the purposes of medical diagnosis, therapeutic monitoring, disease outbreak containment, and disease prevention. Detection dogs are proven to be a valuable real-time mobile detection technology for the detection of VOC related to explosives, narcotics, humans, and many other targets of interests. Little is known about what dogs are detecting when searching for biological targets. It is important to understand where biological VOC originates and how dogs might be able to detect biological targets. This review paper discusses the recent scientific literature involving VOC analysis and postulates potential biological targets for canine detection. Dogs have shown their ability to detect pathogen and disease-specific VOC. Future research will determine if dogs can be employed operationally in hospitals, on borders, in underserved areas, on farms, and in other operational environments to give real-time feedback on the presence of a biological target. Frontiers Media S.A. 2016-06-24 /pmc/articles/PMC4919317/ /pubmed/27446935 http://dx.doi.org/10.3389/fvets.2016.00047 Text en Copyright © 2016 Angle, Waggoner, Ferrando, Haney and Passler. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Angle, Craig
Waggoner, Lowell Paul
Ferrando, Arny
Haney, Pamela
Passler, Thomas
Canine Detection of the Volatilome: A Review of Implications for Pathogen and Disease Detection
title Canine Detection of the Volatilome: A Review of Implications for Pathogen and Disease Detection
title_full Canine Detection of the Volatilome: A Review of Implications for Pathogen and Disease Detection
title_fullStr Canine Detection of the Volatilome: A Review of Implications for Pathogen and Disease Detection
title_full_unstemmed Canine Detection of the Volatilome: A Review of Implications for Pathogen and Disease Detection
title_short Canine Detection of the Volatilome: A Review of Implications for Pathogen and Disease Detection
title_sort canine detection of the volatilome: a review of implications for pathogen and disease detection
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919317/
https://www.ncbi.nlm.nih.gov/pubmed/27446935
http://dx.doi.org/10.3389/fvets.2016.00047
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