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Paclitaxel-Coated Balloons: Investigation of Drug Transfer in Healthy and Atherosclerotic Arteries – First Experimental Results in Rabbits at Low Inflation Pressure

PURPOSE: Beyond antiproliferative properties, paclitaxel exhibits anti-inflammatory activity, which might be beneficial in the local treatment of nonocclusive coronary artery disease. Paclitaxel release and tissue concentrations after paclitaxel-coated balloon treatment using different pressures hav...

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Autores principales: Stolzenburg, Nicola, Breinl, Janni, Bienek, Stephanie, Jaguszewski, Milosz, Löchel, Melanie, Taupitz, Matthias, Speck, Ulrich, Wagner, Susanne, Schnorr, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919377/
https://www.ncbi.nlm.nih.gov/pubmed/27033233
http://dx.doi.org/10.1007/s10557-016-6658-1
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author Stolzenburg, Nicola
Breinl, Janni
Bienek, Stephanie
Jaguszewski, Milosz
Löchel, Melanie
Taupitz, Matthias
Speck, Ulrich
Wagner, Susanne
Schnorr, Jörg
author_facet Stolzenburg, Nicola
Breinl, Janni
Bienek, Stephanie
Jaguszewski, Milosz
Löchel, Melanie
Taupitz, Matthias
Speck, Ulrich
Wagner, Susanne
Schnorr, Jörg
author_sort Stolzenburg, Nicola
collection PubMed
description PURPOSE: Beyond antiproliferative properties, paclitaxel exhibits anti-inflammatory activity, which might be beneficial in the local treatment of nonocclusive coronary artery disease. Paclitaxel release and tissue concentrations after paclitaxel-coated balloon treatment using different pressures have not been investigated so far. The aim of the study was to investigate in an atherosclerotic rabbit model whether drug transfer from paclitaxel-coated balloons into the vessel wall is affected by the presence of atherosclerotic lesions and to which extent it depends on the inflation pressure used. METHODS: Paclitaxel-coated balloons (3.5 μg/mm(2) paclitaxel) were inflated with pressures of 1, 2, or 6 atm (60s) in healthy (n = 39) and atherosclerotic (n = 22) arteries of New Zealand White Rabbits. Paclitaxel content in arterial walls (10 min after interventions) and paclitaxel remaining on balloons after treatment were analyzed using high-performance liquid chromatography. RESULTS: Median paclitaxel tissue concentrations were 829.3 μg/g (IQR 636.5–1487 μg/g) in healthy and 375.7 μg/g (IQR 169.8–771.6 μg/g) in atherosclerotic arteries (p = 0.0002). The paclitaxel tissue concentration was dependent on inflation pressure (1 atm vs. 2 atm vs. 6 atm) in atherosclerotic arteries (p = 0.0106) but not in healthy arteries (p ≥ 0.05). CONCLUSIONS: Atherosclerotic lesions impede the transfer of paclitaxel into arterial walls. Higher inflation pressures resulted in an increased paclitaxel transfer in atherosclerotic but not in healthy arteries. However, it is assumed that the tissue concentrations achieved with an inflation pressure of 2 atm are potentially effective in this model.
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spelling pubmed-49193772016-07-07 Paclitaxel-Coated Balloons: Investigation of Drug Transfer in Healthy and Atherosclerotic Arteries – First Experimental Results in Rabbits at Low Inflation Pressure Stolzenburg, Nicola Breinl, Janni Bienek, Stephanie Jaguszewski, Milosz Löchel, Melanie Taupitz, Matthias Speck, Ulrich Wagner, Susanne Schnorr, Jörg Cardiovasc Drugs Ther Original Article PURPOSE: Beyond antiproliferative properties, paclitaxel exhibits anti-inflammatory activity, which might be beneficial in the local treatment of nonocclusive coronary artery disease. Paclitaxel release and tissue concentrations after paclitaxel-coated balloon treatment using different pressures have not been investigated so far. The aim of the study was to investigate in an atherosclerotic rabbit model whether drug transfer from paclitaxel-coated balloons into the vessel wall is affected by the presence of atherosclerotic lesions and to which extent it depends on the inflation pressure used. METHODS: Paclitaxel-coated balloons (3.5 μg/mm(2) paclitaxel) were inflated with pressures of 1, 2, or 6 atm (60s) in healthy (n = 39) and atherosclerotic (n = 22) arteries of New Zealand White Rabbits. Paclitaxel content in arterial walls (10 min after interventions) and paclitaxel remaining on balloons after treatment were analyzed using high-performance liquid chromatography. RESULTS: Median paclitaxel tissue concentrations were 829.3 μg/g (IQR 636.5–1487 μg/g) in healthy and 375.7 μg/g (IQR 169.8–771.6 μg/g) in atherosclerotic arteries (p = 0.0002). The paclitaxel tissue concentration was dependent on inflation pressure (1 atm vs. 2 atm vs. 6 atm) in atherosclerotic arteries (p = 0.0106) but not in healthy arteries (p ≥ 0.05). CONCLUSIONS: Atherosclerotic lesions impede the transfer of paclitaxel into arterial walls. Higher inflation pressures resulted in an increased paclitaxel transfer in atherosclerotic but not in healthy arteries. However, it is assumed that the tissue concentrations achieved with an inflation pressure of 2 atm are potentially effective in this model. Springer US 2016-04-01 2016 /pmc/articles/PMC4919377/ /pubmed/27033233 http://dx.doi.org/10.1007/s10557-016-6658-1 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Stolzenburg, Nicola
Breinl, Janni
Bienek, Stephanie
Jaguszewski, Milosz
Löchel, Melanie
Taupitz, Matthias
Speck, Ulrich
Wagner, Susanne
Schnorr, Jörg
Paclitaxel-Coated Balloons: Investigation of Drug Transfer in Healthy and Atherosclerotic Arteries – First Experimental Results in Rabbits at Low Inflation Pressure
title Paclitaxel-Coated Balloons: Investigation of Drug Transfer in Healthy and Atherosclerotic Arteries – First Experimental Results in Rabbits at Low Inflation Pressure
title_full Paclitaxel-Coated Balloons: Investigation of Drug Transfer in Healthy and Atherosclerotic Arteries – First Experimental Results in Rabbits at Low Inflation Pressure
title_fullStr Paclitaxel-Coated Balloons: Investigation of Drug Transfer in Healthy and Atherosclerotic Arteries – First Experimental Results in Rabbits at Low Inflation Pressure
title_full_unstemmed Paclitaxel-Coated Balloons: Investigation of Drug Transfer in Healthy and Atherosclerotic Arteries – First Experimental Results in Rabbits at Low Inflation Pressure
title_short Paclitaxel-Coated Balloons: Investigation of Drug Transfer in Healthy and Atherosclerotic Arteries – First Experimental Results in Rabbits at Low Inflation Pressure
title_sort paclitaxel-coated balloons: investigation of drug transfer in healthy and atherosclerotic arteries – first experimental results in rabbits at low inflation pressure
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919377/
https://www.ncbi.nlm.nih.gov/pubmed/27033233
http://dx.doi.org/10.1007/s10557-016-6658-1
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