Cargando…

The Dimeric Architecture of Checkpoint Kinases Mec1(ATR) and Tel1(ATM) Reveal a Common Structural Organization

The phosphatidylinositol 3-kinase-related protein kinases are key regulators controlling a wide range of cellular events. The yeast Tel1 and Mec1·Ddc2 complex (ATM and ATR-ATRIP in humans) play pivotal roles in DNA replication, DNA damage signaling, and repair. Here, we present the first structural...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sawicka, Marta, Wanrooij, Paulina H., Darbari, Vidya C., Tannous, Elias, Hailemariam, Sarem, Bose, Daniel, Makarova, Alena V., Burgers, Peter M., Zhang, Xiaodong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	DNA and Chromosomes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919432/ https://www.ncbi.nlm.nih.gov/pubmed/27129217 http://dx.doi.org/10.1074/jbc.M115.708263

Ejemplares similares

Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway
por: Liu, Yiyong, et al.
Publicado: (2010)

Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex
por: Lee, Ji-Hoon, et al.
Publicado: (2013)

Characterization of Spindle Checkpoint Kinase Mps1 Reveals Domain with Functional and Structural Similarities to Tetratricopeptide Repeat Motifs of Bub1 and BubR1 Checkpoint Kinases
por: Lee, Semin, et al.
Publicado: (2012)

Activation of Saccharomyces cerevisiae Mlh1-Pms1 Endonuclease in a Reconstituted Mismatch Repair System
por: Smith, Catherine E., et al.
Publicado: (2015)

Xenopus laevis Ctc1-Stn1-Ten1 (xCST) Protein Complex Is Involved in Priming DNA Synthesis on Single-stranded DNA Template in Xenopus Egg Extract
por: Nakaoka, Hidenori, et al.
Publicado: (2012)

DNA Methylation-mediated Down-regulation of DNA Methyltransferase-1 (DNMT1) Is Coincident with, but Not Essential for, Global Hypomethylation in Human Placenta
por: Novakovic, Boris, et al.
Publicado: (2010)

Endonuclease EEPD1 Is a Gatekeeper for Repair of Stressed Replication Forks
por: Kim, Hyun-Suk, et al.
Publicado: (2017)

The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair
por: Breslin, Claire, et al.
Publicado: (2017)

Alternative Modes of Binding of Poly(ADP-ribose) Polymerase 1 to Free DNA and Nucleosomes
por: Clark, Nicholas J., et al.
Publicado: (2012)

Inositol Pyrophosphate Synthesis by Inositol Hexakisphosphate Kinase 1 Is Required for Homologous Recombination Repair
por: Jadav, Rathan S., et al.
Publicado: (2013)

Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription
por: Kollenstart, Leonie, et al.
Publicado: (2019)

Automethylation Activities within the Mixed Lineage Leukemia-1 (MLL1) Core Complex Reveal Evidence Supporting a “Two-active Site” Model for Multiple Histone H3 Lysine 4 Methylation
por: Patel, Anamika, et al.
Publicado: (2014)

The Shelterin Component TPP1 Is a Binding Partner and Substrate for the Deubiquitinating Enzyme USP7
por: Zemp, Ivo, et al.
Publicado: (2014)

Phosphorylation by Casein Kinase 2 Facilitates Psh1 Protein-assisted Degradation of Cse4 Protein
por: Hewawasam, Geetha S., et al.
Publicado: (2014)

DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction
por: Algasaier, Sana I., et al.
Publicado: (2016)

Cryo-EM Structure of Nucleotide-Bound Tel1(ATM) Unravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations
por: Yates, Luke A., et al.
Publicado: (2020)

RNase H1 promotes replication fork progression through oppositely transcribed regions of Drosophila mitochondrial DNA
por: González de Cózar, Jose M., et al.
Publicado: (2019)

Protein Kinase A-mediated Serine 35 Phosphorylation Dissociates Histone H1.4 from Mitotic Chromosome
por: Chu, Chi-Shuen, et al.
Publicado: (2011)

The SKP1-Cul1-F-box and Leucine-rich Repeat Protein 4 (SCF-FbxL4) Ubiquitin Ligase Regulates Lysine Demethylase 4A (KDM4A)/Jumonji Domain-containing 2A (JMJD2A) Protein
por: Van Rechem, Capucine, et al.
Publicado: (2011)

The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase
por: Franzolin, Elisa, et al.
Publicado: (2015)

UL52 Primase Interactions in the Herpes Simplex Virus 1 Helicase-Primase Are Affected by Antiviral Compounds and Mutations Causing Drug Resistance
por: Muylaert, Isabella, et al.
Publicado: (2014)

The finger loop of the SRA domain in the E3 ligase UHRF1 is a regulator of ubiquitin targeting and is required for the maintenance of DNA methylation
por: Vaughan, Robert M., et al.
Publicado: (2019)

HIV-1 Viral Infectivity Factor (Vif) Alters Processive Single-stranded DNA Scanning of the Retroviral Restriction Factor APOBEC3G
por: Feng, Yuqing, et al.
Publicado: (2013)

Two separate pathways regulate protein stability of ATM/ATR-related protein kinases Mec1 and Tel1 in budding yeast
por: Goto, Greicy H., et al.
Publicado: (2017)

Mechanism of Auto-inhibition and Activation of Mec1(ATR) Checkpoint Kinase
por: Tannous, Elias A., et al.
Publicado: (2020)

The Linker Region of MacroH2A Promotes Self-association of Nucleosomal Arrays
por: Muthurajan, Uma M., et al.
Publicado: (2011)

Identification of Noncoding Transcripts from within CENP-A Chromatin at Fission Yeast Centromeres
por: Choi, Eun Shik, et al.
Publicado: (2011)

UV Damage in DNA Promotes Nucleosome Unwrapping
por: Duan, Ming-Rui, et al.
Publicado: (2010)

Molecular Cooperation between the Werner Syndrome Protein and Replication Protein A in Relation to Replication Fork Blockage
por: Machwe, Amrita, et al.
Publicado: (2011)

A Human PMS2 Homologue from Aquifex aeolicus Stimulates an ATP-dependent DNA Helicase
por: Mauris, Jerome, et al.
Publicado: (2010)

MutLα and Proliferating Cell Nuclear Antigen Share Binding Sites on MutSβ
por: Iyer, Ravi R., et al.
Publicado: (2010)

Magnesium Coordination Controls the Molecular Switch Function of DNA Mismatch Repair Protein MutS
por: Lebbink, Joyce H. G., et al.
Publicado: (2010)

Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family
por: Hillringhaus, Lars, et al.
Publicado: (2011)

Monoubiquitinated Histone H2A Destabilizes Photolesion-containing Nucleosomes with Concomitant Release of UV-damaged DNA-binding Protein E3 Ligase
por: Lan, Li, et al.
Publicado: (2012)

A Conserved Function for the H2A.Z C Terminus
por: Wratting, Daniel, et al.
Publicado: (2012)

The Escherichia coli Clamp Loader Can Actively Pry Open the β-Sliding Clamp
por: Paschall, Christopher O., et al.
Publicado: (2011)

Human HEL308 Localizes to Damaged Replication Forks and Unwinds Lagging Strand Structures
por: Tafel, Agnieszka A., et al.
Publicado: (2011)

Scm3 Is a Centromeric Nucleosome Assembly Factor
por: Shivaraju, Manjunatha, et al.
Publicado: (2011)

MCM2-7 Form Double Hexamers at Licensed Origins in Xenopus Egg Extract
por: Gambus, Agnieszka, et al.
Publicado: (2011)

A Conserved Motif in the C-terminal Tail of DNA Polymerase α Tethers Primase to the Eukaryotic Replisome
por: Kilkenny, Mairi L., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_7jnagvdc9d4aqkt441qr1iqjcv