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Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A(3), a Neutrophil-activating Eicosanoid

Eicosanoids are important mediators of fever, pain, and inflammation that modulate cell signaling during acute and chronic disease. We show by using lipidomics that thrombin-activated human platelets generate a new type of eicosanoid that both stimulates and primes human neutrophil integrin (Mac-1)...

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Detalles Bibliográficos
Autores principales:	Hinz, Christine, Aldrovandi, Maceler, Uhlson, Charis, Marnett, Lawrence J., Longhurst, Hilary J., Warner, Timothy D., Alam, Saydul, Slatter, David A., Lauder, Sarah N., Allen-Redpath, Keith, Collins, Peter W., Murphy, Robert C., Thomas, Christopher P., O'Donnell, Valerie B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Lipids
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919433/ https://www.ncbi.nlm.nih.gov/pubmed/27129261 http://dx.doi.org/10.1074/jbc.M115.700609

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