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Pancreatic β-Cell Death due to Pdx-1 Deficiency Requires Multi-BH Domain Protein Bax but Not Bak

Diabetes develops in Pdx1-haploinsufficient mice due to an increase in β-cell death leading to reduced β-cell mass and decreased insulin secretion. Knockdown of Pdx1 gene expression in mouse MIN6 insulinoma cells induced apoptotic cell death with an increase in Bax activation and knockdown of Bax re...

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Detalles Bibliográficos
Autores principales:	Sun, Juan, Mao, Li-qun, Polonsky, Kenneth S., Ren, De-cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919439/ https://www.ncbi.nlm.nih.gov/pubmed/27137932 http://dx.doi.org/10.1074/jbc.M115.705293

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